Table 1 The consistency scores between BD genes, ID genes and CRG5-FU

From: Epigenomics alternations and dynamic transcriptional changes in responses to 5-fluorouracil stimulation reveal mechanisms of acquired drug resistance of colorectal cancer cells

Gene set

Overlapped DEG a

Consistent DEG b

Consistency score (%) c

Binomial P-valued

BD

54

36

66.67

9.92E−03

ID24

21

15

71.43

3.92E−02

ID48

71

55

77.46

1.88E−06

  1. Abbreviations: BD, basally deregulated; DEG, differentially expressed gene; 5-FU, 5-fluorouracil; ID, inducible difference.
  2. CRG5-FU indicates DEGs between the pre-chemotherapy clinical specimens of responders and nonresponders receiving 5-FU-based chemotherapy; ID genes are genes detected between drug-treated parental cell line and drug-treated resistant cell line; BD genes are basally deregulated genes detected between parental cell line and resistant cell line.
  3. aThe number of BD genes or ID genes overlapped with CRG5-FU.
  4. bThe number of overlapped DEGs with the same deregulation direction.
  5. cThe consistency score of BD genes or ID genes with CRG5-FU.
  6. dThe binominal distribution P-value.
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