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Liccione et al. report the isolation and characterization of neutralizing antibodies targeting the spike protein of the endemic Alphacoronavirus HCoV-229E.
Al-Amoudi and Baradaran et. al. show that cryo-ultramicrotomy can produce vitreous sections as thin as ~40 nm with minimal surface damage, overcoming limitations imposed by focused ion beam–milled lamellae. Using these ultrathin sections, they determine high-resolution, side-chain-level structures of the 50S ribosomal subunit both in vitro (2.8 Å) and in situ (3 Å).
Kinetic analysis of rhabdomyolysis-induced acute kidney injury reveals early tubular injury and immune cell infiltration precede complement activation. Initial protective responses fail quickly, leading to escalating damage. Timing highlights need for early, multi-targeted therapies.
Integrating Nanopore sequencing with machine learning uncovers widespread, predictable lincRNA activation in DNA methylation-deficient Arabidopsis, linking epigenetics to RNA expression.
GIFT15-induced regulatory B cells rely on CCL3 to drive immune modulation and promote recovery in EAE, revealing a key effector pathway with implications for therapeutic remodeling of autoimmune neuroinflammation.
Cend1 as a key protein that enhances mitochondrial ATP production via dimerization and interaction with Atp5f1b, protecting neurons in ischemic stroke. The compound Tianeptine stabilizes Cend1 dimers, boosting ATP and providing neuroprotection in a Cend1-dependent manner.
Promoter hypermethylation-mediated silencing of the tumor suppressor RASA4 activates Ras signaling in small cell lung cancer, thereby driving tumor proliferation, metastasis, and chemoresistance, and revealing its role as a prognostic biomarker.
Filament formation of full-length NONO/SFPQ heterodimers was observed and structurally characterized in vitro which may provide a scaffold for gene regulation, paraspeckle formation and DNA double-strand break repair in vivo.
Enhanced label-free multiphoton skin imaging uses phasor analysis to unmix key endogenous fluorophores, enabling mapping of molecular components in skin of varying pigmentation and metabolic states.
HOXA2 expression was inhibited by aberrant hypermethylation, leading to decreased SIRT1 levels, which could increase ATF6 acetylation and activation as well as subsequent ER stress, resulting in renal damage in CKD-related fibrosis.
Nanosecond pulsed electric fields selectively permeabilize urothelial cancer cells by leveraging their larger size, allowing efficient electroporation at lower field strengths
A focused analysis of the histone proteins and post-translational modifications in single cell proteomics provides insight into the heterogeneity of histone deacetylase inhibition.
In patchouli (Pogostemon cablin), anther-derived somatic embryos were profiled by single-cell RNA-seq to define eight cell types, identifying PcNAC048 that drives embryonic cell differentiation, promotes lateral root development in Arabidopsis, and negatively regulates patchouli alcohol biosynthesis.
A mouse ovarian cancer model MEPP with Pten/Trp53 loss, engineered using the EPI-SauriCas9 system, provides a platform for dissecting ovarian cancer biology and accelerating drug discovery.
Imperatorin stimulates cardiomyocyte DNA repair and proliferation by enhancing the phosphorylation of TDP1 at serine 81 through facilitating the proximity-mediated interaction between TDP1 and DNA-PKcs.
Structure of influenza polymerase bound to the cRNA promoter reveals unique structural features essential for internal initiation, providing insights into the mechanism of viral replication.
