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Authors discuss big bottlenecks that inhibit vascular regeneration in the disease context of aortic aneurysm, stroke, and peripheral artery disease, along with emerging opportunities to overcome these challenges.
Mammalian reproduction hinges on maternal-fetal communication mediated by extracellular vesicles. Their role in diagnostics and therapeutics shows promise, but questions about uptake, cargo delivery, and specific biomolecules remain.
A Mini Review summarizing the current understanding of epithelial-mesenchymal transition (EMT) and 3D genome organization, focusing on the role of chromatin conformation and accessibility changes during the transitional phases of EMT.
Glymphatic and lymphatic communication contribute to the clearance of cerebrospinal fluid and the removal of macromolecules from the brain. Understanding the intricate mechanisms and the circadian influence might revolutionize treatment strategies.
In this Mini Review, the authors discuss the relationship between condensate formation, genome organization, and transcriptional activity, focusing on the experimental evidence behind the role of transcriptional condensates in gene regulation.
