Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
This Article details the methods used for rigorous assessment of disease interventions in a multicenter preclinical trial. Using stroke models as proof of concept, it offers adaptable protocols for any field requiring robust preclinical validation.
The authors used the PiggyBac and CRISPR–Cas9 systems to generate transgenic lines and gene knockouts in the greater wax moth, Galleria mellonella. These approaches are expected to broaden the range of applications for this model in preclinical research.
APOB100 mice on a Western diet develop human-like hyperlipidemia, retinal cholesterol buildup, choroidal cholesterol crystals and impaired retinal function, supporting their use for studying lipid contributions to age-related macular degeneration.
This study introduces IntelliProfiler, a software workflow for radio frequency identification-based analysis of locomotor activity and social spacing in mice, revealing sex, age and autism spectrum disorder model effects, enabling scalable, long-term behavioral phenotyping.
The authors analyzed four melioidosis studies in mice to identify refined humane endpoints (25% weight loss and/or clinical score ≥5) that improve animal welfare while maintaining study integrity.
