Volume 54 Issue 11, November 2025

Recent advancements in mercury bioremediation highlight the potential of engineered organisms to transform toxic mercury into less harmful forms. Two pioneering studies demonstrate the ability of genetically modified animals and bacteria to mitigate mercury toxicity. However, these approaches face challenges, including intracellular toxicity and limited bioconversion efficiency.

This Review examines the role of the gut mycobiome in health and disease states, based on findings from rodent models.

The study compares acclimatization protocols for metabolic cages and found that the standard housing at 23 °C impacts mice’s physiology and welfare owing to cold stress. However, thermoneutral housing provides a simple solution to improve mouse welfare.

By assessing different clinical, behavioral and welfare parameters, the authors demonstrate that the oral administration of tramadol is more suitable than metamizole as on-demand analgesia in mouse models of acute lymphoblastic leukemia.

The authors developed a new behavior classifier using color-based body segmentation that can capture body parts, track body movements and detect subtle behavioral phenotypes in freely moving mice.