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Remote functionalization through alkene isomerization is a popular strategy in organic synthesis. The dynamic nature of alkene isomerization typically leads to difficulties in controlling the stereochemistry of C(sp3) centres along the carbon skeleton. This Review outlines synthetic methods that tackle this issue and leverage alkene isomerization to control C(sp3) stereocentres in complex organic molecules.
Oximes are valuable motifs with diverse reactivity. This Review outlines the breadth of oxime reactivity including N–O bond fragmentation through transition metal catalysis and photocatalysis, [2 + 2]-cycloaddition reactions, asymmetric reduction and applications in materials science. Developments in transition metal catalysis and photocatalysis highlight the use of oximes as powerful synthetic building blocks.
