Nature Genetics in 1994

Analysis of the literature of the effects of consanguinity on mortality puts a figure on the price of inbreeding.

It remains unclear just how big the latest player in the tumour-suppressor league will turn out to be. But p!6 is not about to go away.

A complete physical map of the region encompassing the locus for hereditary breast and ovarian cancer should assist the long-awaited cloning of this important gene.

New strategies for automated genotyping and linkage analysis will bring greater power to the study of complex hereditary disorders.

The search for genetic factors that may predispose people to various allergies takes a promising turn with the publication of some incriminating evidence against the IgE receptor.

The most extensive comparison so far of contiguous genomic DNA in humans and mice reveals a surprising degree of conservation in intergenic sequences.

A linkage map for of the cattle genome points to mechanisms of the reassortment of mammalian genes while a new technique raises questions about the structure of gene-starts in chromatin.

Apart from the usual crop of gene assignments (for hereditary haemorrhagic telanglectasia, for example) this month's issue carries further the genetics of expanding repeating elements.

The first issue of Nature Genetics this year includes the first search for alleles associated with longevity outside the human HLA complex and the seventh neurodegenerative disease associated with a repetitive DNA triplet sequence.