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Volume 43 Issue 3, March 2025

Genetically encoded colored materials

Self-pigmenting textiles grown from cellulose-producing bacteria. Walker et al. engineered bacteria to synthesize a melanin-producing enzyme, allowing them to grow a black material that can substitute for leather in fashion items.

See Walker et al.

Image: Ivy S. Li. Cover design: Erin Dewalt

Volume 43 Issue 3

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  • A recent study found high amounts of microplastics in the human brain. This could spur funding and technological advances for plastic degradation.

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    • The predominance of manufacturing process patents asserted in litigation by originator biologics companies against would-be biosimilar entrants has resulted in a number of Congressional and administrative agency proposals that could increase scrutiny and limit enforceability.

      • Osmat Azzam Jefferson
      • W. Nicholson Price II
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    • Recent patents relating to epigenetic modification and analysis.

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  • A set of 20 computational metrics was evaluated to determine whether they could predict the functionality of synthetic enzyme sequences produced by generative protein models, resulting in the development of a computational filter, COMPSS, that increased experimental success rates by 50–150%, tested in over 500 natural and AI-generated enzymes.

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  • To advance the toolset for controlling plant gene expression, we developed a CRISPR interference-based platform for the construction of synthetic Boolean logic gates that is functional in multiple plant species. These genetic circuits are programmable and reversible in nature, which will enable spatiotemporal control of plant responses to dynamic cues.

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