Method to Watch in 2018

Improved luciferases and luciferins are poised to shine.

Synthetic approaches help to dissect the complexity of microbial interactions.

Tools are needed to study phase behaviors of membraneless compartments in living cells.

Engineered genome structure explores function.

Machine learning approaches that include deep learning are moving beyond image classification to change the way images are made.

New technologies bring single-cell proteomics closer to reality.

The rich repertoire of T cell receptors is awaiting large-scale profiling.

Genetically encoded neurotransmitter sensors will shed light on neuronal communication.

Recent advances in mass spectrometry imaging enable label-free molecular mapping in single cells and in 3D.

New X-ray free-electron (XFEL) facilities will broaden access to this technology, facilitate methods development, and push boundaries in structural biology.

Fluorescence nanoscopy is extending its reach into structural biology.

Increases in throughput push electrophysiology into a new era.

Sophisticated barcoding approaches are transforming cell lineaging.

In the era of big data, neuroscience can profit from deep-learning approaches.

It will soon be commonplace to localize gene expression in tissues.

Sequencing and imaging bring unique aspects to genome architecture.