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Preserving spatial information in gene expression analyses is key for interpreting the single-cell tissue context (and even subcellular environments) of RNAs to achieve a more complete understanding of the underlying physiology. This Innovation article describes the emerging technologies of and biological insights from spatially resolved transcriptomics technologies, and how they set the stage for comprehensive investigations using complementary omic approaches.
Ribosome profiling is a recently developed technique that uses deep sequencing to study translationin vivo. This approach has provided new insights into the identities and amounts of proteins produced by cells, as well as into the mechanism of protein synthesis itself.
