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This Opinion article proposes that interleukin-15 (IL-15) is a master regulator of tissue-specific T cell responses to promote the destruction of infected cells. Hence, dysregulation of IL-15 production in tissues during sterile inflammation can lead to T cell-mediated autoimmunity.
The enormous potential offered by chromatin profiling to reveal the past, present and future activity of a cell, as well as its ability to respond to the tissue environment, warrants the widespread use of this technique in immunological research.
Improved treatments are needed for nearly all forms ofMycobacterium tuberculosisinfection. Adjunctive agents that target the host have the potential to shorten treatment duration, prevent resistance and reduce lung injury by promoting macrophage effector mechanisms and blocking mechanisms that cause lung destruction.
