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SIMIBI-type NTP-binding proteins are an ancient subfamily of nucleotide-binding proteins that comprises both dimeric ATPases and GTPases (SIMIBI 'twins'). This Perspective focuses on a subset of SIMIBI proteins with a defined function in protein targeting and localization, and aims to define common mechanistic principles and differences for these proteins.
Whereas post-translational modifications (PTMs) in histone tails are well characterized, functional and mechanistic insights into PTMs in the globular nucleosome core have been lacking. This Perspective covers recent advances in the understanding of lateral-surface PTMs and their effects on nucleosome and chromatin dynamics.
