Nature Search

Gtf2i-encoded transcription factor Tfii-i regulates myelination via Sox10 and Mbp regulatory elements

The transcriptional regulation of oligodendrocytes has an essential role in myelin formation and maintenance. Here, the authors identify the transcription factor Tfii-i as a regulator of myelin genes expression in the nervous system and show that its loss enhances myelin thickness and nerve conduction.

Gilad Levy
May Rokach
Boaz Barak
ResearchOpen Access26 Sept 2025
Nature Communications

Volume: 16, P: 1-24
Neuronal processes and glial precursors form a scaffold for wiring the developing mouse cochlea

In developing embryos, axons grow through complex and dynamic terrains. Here, the authors show that spiral ganglion neurons in the developing mouse cochlea extend leading axons that interact with a scaffold of glial precursors, with follower axons fasciculating on top.

N. R. Druckenbrod
E. B. Hale
L. V. Goodrich
ResearchOpen Access17 Nov 2020
Nature Communications

Volume: 11, P: 1-11
An atlas of late prenatal human neurodevelopment resolved by single-nucleus transcriptomics

Late prenatal development of the human neocortex encompasses a critical period of gliogenesis and cortical expansion. Here, authors use human transcriptomics to capture transience and diversity of cells in middle and late prenatal development, including glial progenitor signatures.

Susana I. Ramos
Zarmeen M. Mussa
Nadejda M. Tsankova
ResearchOpen Access12 Dec 2022
Nature Communications

Volume: 13, P: 1-18
Sirt2 promotes white matter oligodendrogenesis during development and in models of neonatal hypoxia

Neonatal hypoxia leads to white matter hypomyelination due to delayed oligodendrocyte maturation. The authors identify Sirt2 as a crucial regulator of oligodendrocyte differentiation during normal white matter development and in response to hypoxia.

Beata Jablonska
Katrina L. Adams
Vittorio Gallo
ResearchOpen Access15 Aug 2022
Nature Communications

Volume: 13, P: 1-20
Impaired bidirectional communication between interneurons and oligodendrocyte precursor cells affects social cognitive behavior

Early postnatal interruption of the bidirectional GABA/TNFSF12 signaling between parvalbumin-positive interneurons and oligodendrocyte precursor cells impairs correct prefrontal cortical network activity and social cognitive behavior later in life.

Li-Pao Fang
Na Zhao
Xianshu Bai
ResearchOpen Access16 Mar 2022
Nature Communications

Volume: 13, P: 1-14
hESC-derived Olig2⁺ progenitors generate a subtype of astroglia with protective effects against ischaemic brain injury

Astroglia are heterogeneous in phenotype and not all astrocytes are equivalent in their ability to repair injured brain. Here, the authors show that two defined subtypes of astroglia generated from hESC-derived Olig2-positive versus Olig2-negative neural progenitors, exhibit distinct properties and neuroprotective effects.

Peng Jiang
Chen Chen
Wenbin Deng
ResearchOpen Access23 Jul 2013
Nature Communications

Volume: 4, P: 1-16
A new subtype of progenitor cell in the mouse embryonic neocortex

The authors report that radial glia–like (oRG) progenitor cells are present in the mouse embryonic cortex and that these cells arise from asymmetric divisions of radial glia. In turn, they undergo asymmetric divisions to generate neurons.

Xiaoqun Wang
Jin-Wu Tsai
Arnold R Kriegstein
Research10 Apr 2011
Nature Neuroscience

Volume: 14, P: 555-561
Cenpj/CPAP regulates progenitor divisions and neuronal migration in the cerebral cortex downstream of Ascl1

The proneural factor Ascl1/Mash1 is an important regulator of embryonic neurogenesis. Here the authors identify that the microcephaly protein Cenpj/CPAP is essential for several microtubule-dependent steps in the neurogenic program driven by Ascl1 in the developing cerebral cortex.

Patricia P. Garcez
Javier Diaz-Alonso
François Guillemot
ResearchOpen Access10 Mar 2015
Nature Communications

Volume: 6, P: 1-14
Single-cell analysis reveals transcriptional heterogeneity of neural progenitors in human cortex

The developing human cortex contains diverse populations of neural progenitor cells, including a large proportion of outer radial glia (ORG), a progenitor type that is rare in the mouse. The authors identify a transcriptional signature of ORG characterized by markers of neuronal lineage fate and use single-cell analyses to contrast the heterogeneity of cortical progenitors across human, mouse and ferret.

Matthew B Johnson
Peter P Wang
Christopher A Walsh
Research03 Mar 2015
Nature Neuroscience

Volume: 18, P: 637-646
GABAergic regulation of cerebellar NG2 cell development is altered in perinatal white matter injury

The authors show that chronic neonatal hypoxia reduces GABA_A receptor–mediated signaling to oligodendrocyte precursor cells in the cerebellar white matter and enhances their proliferation, delays oligodendrocyte maturation and disrupts myelination. Following hypoxia, treatment with a GABA uptake blocker restores myelination.

Marzieh Zonouzi
Joseph Scafidi
Vittorio Gallo
Research30 Mar 2015
Nature Neuroscience

Volume: 18, P: 674-682
Enteric nervous system development: what could possibly go wrong?

The gastrointestinal tract is innervated by the enteric nervous system (ENS), and disruption of ENS development can result in various gastrointestinal disorders. Here, Rao and Gershon review the complex processes involved in ENS development, including cell migration, proliferation and organization.

Meenakshi Rao
Michael D. Gershon
Reviews25 Jul 2018
Nature Reviews Neuroscience

Volume: 19, P: 552-565
Functional diversity of astrocytes in neural circuit regulation

Emerging evidence suggests that astrocytes may be as diverse in their physiological and functional characteristics as neurons. Ben Haim and Rowitch describe astrocyte heterogeneity, consider the mechanisms by which such diversity may arise and discuss the consequences of its disruption in disease.

Lucile Ben Haim
David H. Rowitch
Reviews01 Dec 2016
Nature Reviews Neuroscience

Volume: 18, P: 31-41
Cell Fate Potential of NG2 Progenitors

Rebeca Sánchez-González
Ana Bribián
Laura López-Mascaraque
ResearchOpen Access18 Jun 2020
Scientific Reports

Volume: 10, P: 1-12
Laminin α2, α4, and α5 Chains Positively Regulate Migration and Survival of Oligodendrocyte Precursor Cells

Nobuharu Suzuki
Mai Hyodo
Chihiro Akazawa
ResearchOpen Access27 Dec 2019
Scientific Reports

Volume: 9, P: 1-9
Oxygen impairs oligodendroglial development via oxidative stress and reduced expression of HIF-1α

Christina Brill
Till Scheuer
Thomas Schmitz
ResearchOpen Access23 Feb 2017
Scientific Reports

Volume: 7, P: 1-16
Migrating Oligodendrocyte Progenitor Cells Swell Prior to Soma Dislocation

Patrick Happel
Kerstin Möller
Irmgard D. Dietzel
ResearchOpen Access09 May 2013
Scientific Reports

Volume: 3, P: 1-9
NG2-cells are not the cell of origin for murine neurofibromatosis-1 (Nf1) optic glioma

A C Solga
S M Gianino
D H Gutmann
Research14 Jan 2013
Oncogene

Volume: 33, P: 289-299

Search

Gtf2i-encoded transcription factor Tfii-i regulates myelination via Sox10 and Mbp regulatory elements

Neuronal processes and glial precursors form a scaffold for wiring the developing mouse cochlea

An atlas of late prenatal human neurodevelopment resolved by single-nucleus transcriptomics

Sirt2 promotes white matter oligodendrogenesis during development and in models of neonatal hypoxia

Impaired bidirectional communication between interneurons and oligodendrocyte precursor cells affects social cognitive behavior

hESC-derived Olig2⁺ progenitors generate a subtype of astroglia with protective effects against ischaemic brain injury

A new subtype of progenitor cell in the mouse embryonic neocortex

Cenpj/CPAP regulates progenitor divisions and neuronal migration in the cerebral cortex downstream of Ascl1

Single-cell analysis reveals transcriptional heterogeneity of neural progenitors in human cortex

GABAergic regulation of cerebellar NG2 cell development is altered in perinatal white matter injury

Enteric nervous system development: what could possibly go wrong?

Functional diversity of astrocytes in neural circuit regulation

Cell Fate Potential of NG2 Progenitors

Laminin α2, α4, and α5 Chains Positively Regulate Migration and Survival of Oligodendrocyte Precursor Cells

Oxygen impairs oligodendroglial development via oxidative stress and reduced expression of HIF-1α

Migrating Oligodendrocyte Progenitor Cells Swell Prior to Soma Dislocation

NG2-cells are not the cell of origin for murine neurofibromatosis-1 (Nf1) optic glioma

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