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Adipose tissue hyaluronan production improves systemic glucose homeostasis and primes adipocytes for CL 316,243-stimulated lipolysis

Hyaluronan is a naturally occurring linear polysaccharide that together with collagens, enzymes, and glycoproteins forms the extracellular matrix. Here the authors show that adipose tissue overproduction of Hyaluronan reduces fat accumulation in mice fed high-fat diet and improves systemic glucose homeostasis.

Yi Zhu
Na Li
Philipp E. Scherer
ResearchOpen Access10 Aug 2021
Nature Communications

Volume: 12, P: 1-15
Distinct functional properties of murine perinatal and adult adipose progenitor subpopulations

Zhang et al. use single-cell transcriptomics to map the cellular landscape of perinatal murine epididymal adipose tissue, and demonstrate that altering the adipogenic capacity of perinatal adipose progenitors has long-term effects on progenitor plasticity, tissue expandability and metabolic health in adulthood.

Qianbin Zhang
Bo Shan
Rana K. Gupta
Research18 Aug 2022
Nature Metabolism

Volume: 4, P: 1055-1070
Perivascular mesenchymal cells control adipose-tissue macrophage accrual in obesity

PDGFRβ⁺ perivascular mesenchymal cells are shown to regulate chronic adipose-tissue inflammation in obesity through downregulation of ZFP423, a transcriptional corepressor of NF-κB.

Bo Shan
Mengle Shao
Rana K. Gupta
Research02 Nov 2020
Nature Metabolism

Volume: 2, P: 1332-1349
De novo adipocyte differentiation from Pdgfrβ⁺ preadipocytes protects against pathologic visceral adipose expansion in obesity

Adipocyte hyperplasia is thought to have beneficial metabolic effects in obesity, but definitive evidence is lacking. Here, Shao et al. promote de novo formation of adipocytes in visceral white adipose tissue (WAT) of adult mice through inducible overexpression of Pparg in Pdgfrβ⁺ preadipocytes and show that this protects from pathological WAT remodeling.

Mengle Shao
Lavanya Vishvanath
Rana K. Gupta
ResearchOpen Access01 Mar 2018
Nature Communications

Volume: 9, P: 1-16

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Adipose tissue hyaluronan production improves systemic glucose homeostasis and primes adipocytes for CL 316,243-stimulated lipolysis

Distinct functional properties of murine perinatal and adult adipose progenitor subpopulations

Perivascular mesenchymal cells control adipose-tissue macrophage accrual in obesity

De novo adipocyte differentiation from Pdgfrβ+ preadipocytes protects against pathologic visceral adipose expansion in obesity

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De novo adipocyte differentiation from Pdgfrβ⁺ preadipocytes protects against pathologic visceral adipose expansion in obesity