This paper reports the first crystal and electron microscopy structure of an individual septin and a heteromeric complex as well as linear septin filaments. The structure reveals that the G domain, which is conserved amongst all septins, serves as a universal building block for formation of a polymer. This domain interacts with other septins via conserved residues.
- Minhajuddin Sirajuddin
- Marian Farkasovsky
- Alfred Wittinghofer
