Nature Search

Deferiprone ameliorates cisplatin induced peripheral neurotoxicity via ferritinophagy adjustment

Hanan Seddiek
Mira Hanna
Mohamed Mansour Khalifa
ResearchOpen Access06 Feb 2025
Scientific Reports

Volume: 15, P: 1-18
Synaptic mechanisms underlying onset and progression of memory deficits caused by hippocampal and midbrain synucleinopathy

Attilio Iemolo
Maria De Risi
Elvira De Leonibus
ResearchOpen Access16 Jun 2023
npj Parkinson's Disease

Volume: 9, P: 1-15
Amine-modified single-walled carbon nanotubes protect neurons from injury in a rat stroke model

Pretreating rats with amine-modified single-walled carbon nanotubes can decrease brain injury and enhance recovery of behavioural functions after a stroke.

Hyun Jung Lee
Jiae Park
Sung Su Kim
Research30 Jan 2011
Nature Nanotechnology

Volume: 6, P: 121-125
Elbow motion in the immunoglobulins involves a molecular ball-and-socket joint

Arthur M. Lesk
Cyrus Chothia
Research08 Sept 1988
Nature

Volume: 335, P: 188-190
Contribution of mGluR5 to pathophysiology in a mouse model of human chromosome 16p11.2 microdeletion

Microdeletions of chromosome 16p11.2 can cause autism, but the pathogenic mechanisms remain unclear. Here the authors show that in a 16p11.2 mouse model, mGluR5 synaptic plasticity and protein synthesis are altered and that a modulator of mGluR5 reverses the cognitive deficits.

Di Tian
Laura J Stoppel
Mark F Bear
Research12 Jan 2015
Nature Neuroscience

Volume: 18, P: 182-184
Site-specific cleavage of single-stranded DNAs at unique sites by a copper-dependent redox reaction

Sergey A. Kazakov
Tatiana G. Astashkina
Valentin V. Vlassov
Research08 Sept 1988
Nature

Volume: 335, P: 186-188
Loss of ETHE1, a mitochondrial dioxygenase, causes fatal sulfide toxicity in ethylmalonic encephalopathy

Ethylmalonic encephalopathy is an autosomal recessive developmental disorder that is characterized by chronic diarrhea and multiple neurological deficits. It is associated with loss-of-function mutations in the ETHE1 gene. Now, Massimo Zeviani and his colleagues report that ETHE1 is a dioxygenase that is responsible for breaking down toxic sulfide in a variety of organs.

Valeria Tiranti
Carlo Viscomi
Massimo Zeviani
Research11 Jan 2009
Nature Medicine

Volume: 15, P: 200-205
The maths of the pop-up tent

Single parameter shows the easiest way to pack up camp.

Philip Ball
News18 Dec 2012
Nature
Mitochondrial respiration in microglia is essential for response to demyelinating injury but not proliferation

Microglia rely on mitochondrial respiration to respond to demyelinating injury. However, mitochondrial respiration is not required to support microglial proliferation.

Joshua S. Stoolman
Rogan A. Grant
Navdeep S. Chandel
Research24 Jul 2024
Nature Metabolism

Volume: 6, P: 1492-1504
CNeuroMod-THINGS, a densely-sampled fMRI dataset for visual neuroscience

Marie St-Laurent
Basile Pinsard
Martin N. Hebart
ResearchOpen Access29 Jan 2026
Scientific Data

Volume: 13, P: 1-17
Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM

Ulf Korthäuer
Daniel Graf
Richard A. Kroczek
Research11 Feb 1993
Nature

Volume: 361, P: 539-541
Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia

John B. Davis
Julie Gray
Steven A. Sheardown
Research11 May 2000
Nature

Volume: 405, P: 183-187
A step towards optimal dialysate bicarbonate concentration

The optimal dialysate bicarbonate concentration is one that prevents acidosis at the beginning of the next dialysis session while avoiding postdialysis alkalosis. Few studies have assessed the effect of different dialysate bicarbonate levels on patient outcomes, but Tentori et al. now report that high dialysate bicarbonate concentrations may contribute to adverse outcomes.

Carlo Basile
Carlo Lomonte
News & Views13 Aug 2013
Nature Reviews Nephrology

Volume: 9, P: 565-566
Induction of human IgE synthesis in B cells by mast cells and basophils

Jean-François Gauchat
Sybille Henchoz
Jean-Yves Bonnefoy
Research23 Sept 1993
Nature

Volume: 365, P: 340-343
A modular framework for multi-scale tissue imaging and neuronal segmentation

Tools to segment cellular and sub-cellular neuronal structures can be hindered by high neuronal density and low signal-to-noise in thick samples. Here, the authors present SENPAI, a framework for imaging and segmenting neurons from conventional and super-resolution microscopy of clarified brain tissues.

Simone Cauzzo
Ester Bruno
Nicola Vanello
ResearchOpen Access22 May 2024
Nature Communications

Volume: 15, P: 1-17
Inhibition of casein kinase 1 δ/ε improves cognitive performance in adult C57BL/6J mice

Heather Mahoney
Emily Peterson
Danielle Gulick
ResearchOpen Access26 Feb 2021
Scientific Reports

Volume: 11, P: 1-13
Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand

Iqbal S. Grewal
Jianchao Xu
Richard A. Flavell
Research07 Dec 1995
Nature

Volume: 378, P: 617-620
Synaptic scaffolding protein Homer1a protects against chronic inflammatory pain

Anke Tappe
Matthias Klugmann
Rohini Kuner
Research21 May 2006
Nature Medicine

Volume: 12, P: 677-681
Tracking the ultraviolet-induced photochemistry of thiophenone during and after ultrafast ring opening

Photoinduced isomerization reactions, including ring-opening reactions, lie at the heart of many chemical processes in nature. The pathway and dynamics of the ring opening of a model heterocycle have now been investigated by femtosecond photoelectron spectroscopy combined with ab initio theory, enabling the visualization of rich dynamics in both the ground and excited electronic states.

Shashank Pathak
Lea M. Ibele
Daniel Rolles
Research20 Jul 2020
Nature Chemistry

Volume: 12, P: 795-800
Control of pain initiation by endogenous cannabinoids

Antonio Calignano
Giovanna La Rana
Daniele Piomelli
Research16 Jul 1998
Nature

Volume: 394, P: 277-281
Chronic Benzodiazepine Administration XI Concurrent Administration of PK11195 Attenuates Lorazepam Discontinuation Effects

John J. Byrnes
Lawrence G. Miller
Richard I. Shader
Research01 May 1993
Neuropsychopharmacology

Volume: 8, P: 267-273
Morphine withdrawal recruits lateral habenula cytokine signaling to reduce synaptic excitation and sociability

The authors show that decreased synaptic efficacy onto raphe-projecting lateral habenula neurons supports opiate withdrawal-induced sociability deficits, and they demonstrate a role for TNF-α signaling in this process.

Kristina Valentinova
Anna Tchenio
Manuel Mameli
Research17 Jun 2019
Nature Neuroscience

Volume: 22, P: 1053-1056
Vagus nerve stimulation does not improve recovery of forelimb motor or somatosensory function in a model of neuropathic pain

Katherine S. Adcock
Tanya Danaphongse
Seth A. Hays
ResearchOpen Access11 Jun 2022
Scientific Reports

Volume: 12, P: 1-7
Plexin B1 is repressed by oncogenic B-Raf signaling and functions as a tumor suppressor in melanoma cells

G M Argast
C H Croy
N G Ahn
Research01 Jun 2009
Oncogene

Volume: 28, P: 2697-2709
Pharmacological characterisation of the highly Na_V1.7 selective spider venom peptide Pn3a

Jennifer R. Deuis
Zoltan Dekan
Irina Vetter
ResearchOpen Access20 Jan 2017
Scientific Reports

Volume: 7, P: 1-19
Ultrafast electronic relaxation pathways of the molecular photoswitch quadricyclane

Light-induced ultrafast switching between the molecular isomers norbornadiene and quadricyclane can reversibly store and release a substantial amount of chemical energy. Two competing pathways have now been identified by which electronically excited quadricyclane molecules relax to the electronic ground state, facilitating interconversion between the two isomers on different timescales.

Kurtis D. Borne
Joseph C. Cooper
Daniel Rolles
ResearchOpen Access02 Feb 2024
Nature Chemistry

Volume: 16, P: 499-505
Pathophysiology of ischemic acute kidney injury

Ischemia is the most common cause of acute kidney injury (AKI) in hospitalized patients. The authors of this Review describe the morphological and functional responses of kidney cells to ischemic injury. They also outline the characteristics of patients who are at highest risk of developing ischemic AKI and discuss therapeutic strategies for the prevention and management of this condition.

Asif A. Sharfuddin
Bruce A. Molitoris
Reviews01 Mar 2011
Nature Reviews Nephrology

Volume: 7, P: 189-200
Structure- and conformation-activity studies of nociceptin/orphanin FQ receptor dimeric ligands

Salvatore Pacifico
Alfonso Carotenuto
Remo Guerrini
ResearchOpen Access06 Apr 2017
Scientific Reports

Volume: 7, P: 1-14
Fiber photometry in striatum reflects primarily nonsomatic changes in calcium

Fiber photometry can record brain dynamics, but the biological source of the signal remains unclear. The authors report that fiber photometry in striatum mainly reflects nonsomatic, and not somatic or spiking-related, changes in calcium.

Alex A. Legaria
Bridget A. Matikainen-Ankney
Alexxai V. Kravitz
Research30 Aug 2022
Nature Neuroscience

Volume: 25, P: 1124-1128
The amygdala is not necessary for the familiarity aspect of recognition memory

It has been proposed that the amygdala is required for the familiarity aspect of item recognition. By studying the performance of monkeys with selective amygdala lesions on four converging memory paradigms, the authors demonstrate that the amygdala is not necessary for familiarity memory, but confirm its role in reward processing.

Benjamin M. Basile
Vincent D. Costa
Elisabeth A. Murray
ResearchOpen Access07 Dec 2023
Nature Communications

Volume: 14, P: 1-14
Targeting ROS production through inhibition of NADPH oxidases

NOXs are vital ROS-producing enzymes with roles in cell function and cancer. Here the authors combine computational and experimental methods to validate inhibitors for human NOX enzymes, opening avenues for redox biology-related cancer drug development.

Joana Reis
Christoph Gorgulla
Andrea Mattevi
Research26 Oct 2023
Nature Chemical Biology

Volume: 19, P: 1540-1550
The transcription factor NF-Y participates to stem cell fate decision and regeneration in adult skeletal muscle

Satellite cells represent myogenic stem cells that allow the homeostasis and repair of adult skeletal muscle. Here the authors report that the transcription factor NF-Y is expressed in satellite cells and is important for their maintenance and proper myogenic differentiation.

Giovanna Rigillo
Valentina Basile
Carol Imbriano
ResearchOpen Access14 Oct 2021
Nature Communications

Volume: 12, P: 1-17
Seasonality affects key physiological pathways in Pontastacus leptodactylus during an Aphanomyces astaci epidemic outbreak

Maria V. Alvanou
Konstantinos Feidantsis
Ioannis A. Giantsis
ResearchOpen Access28 Nov 2025
Scientific Reports

Volume: 15, P: 1-18
The influence of sex difference on behavior and adult hippocampal neurogenesis in C57BL/6 mice

Chi-Hui Tsao
Kuan-Yu Wu
Guo-Jen Huang
ResearchOpen Access12 Oct 2023
Scientific Reports

Volume: 13, P: 1-12
Influence of diurnal phase on behavioral tests of sensorimotor performance, anxiety, learning and memory in mice

Chi-Hui Tsao
Jonathan Flint
Guo-Jen Huang
ResearchOpen Access10 Jan 2022
Scientific Reports

Volume: 12, P: 1-10
Biochemical autoregulatory gene therapy for focal epilepsy

A glutamate-gated chloride channel delivered via gene therapy is shown to detect elevated brain glutamate levels and trigger the suppression of neuronal excitability, thereby attenuating seizure activity in two rodent models of epilepsy.

Andreas Lieb
Yichen Qiu
Dimitri M. Kullmann
Research09 Jul 2018
Nature Medicine

Volume: 24, P: 1324-1329
Synthesis and pharmacological activity of the epimers of hexahydrocannabinol (HHC)

Fabiana Russo
Maria Angela Vandelli
Cinzia Citti
ResearchOpen Access08 Jul 2023
Scientific Reports

Volume: 13, P: 1-11
Whole-genome sequencing of chronic lymphocytic leukemia identifies subgroups with distinct biological and clinical features

Whole-genome sequencing of chronic lymphocytic leukemia from 485 patients identifies putative coding and noncoding drivers of disease. Genomically defined subgroups show distinct clinical and biological characteristics.

Pauline Robbe
Kate E. Ridout
Anna Schuh
ResearchOpen Access04 Nov 2022
Nature Genetics

Volume: 54, P: 1675-1689
Calcium dynamics in habenular astrocytes regulate active coping within behavioral transitions

Tracking of astrocytes dynamics in habenula reveals their contribution to behavioral transitions across species.

Léo Michel
Denys Osypenko
Manuel Mameli
ResearchOpen Access22 Jul 2025
Communications Biology

Volume: 8, P: 1-8
Piezo2 is required for Merkel-cell mechanotransduction

A mouse study shows that non-neuronal epidermal Merkel cells aid fine-touch perception in the skin through their expression of the Piezo2 mechanosensitive cation channel which then actively tunes the response to touch in adjacent somatosensory neurons.

Seung-Hyun Woo
Sanjeev Ranade
Ardem Patapoutian
Research06 Apr 2014
Nature

Volume: 509, P: 622-626
Time-dependent changes in paw carrageenan-induced inflammation above and below the level of low thoracic spinal cord injury in rats

Arianna Rodríguez-Cal y Mayor
Leticia Cruz-Antonio
Gabriel Guízar-Sahagún
Research23 May 2018
Spinal Cord

Volume: 56, P: 964-970
Porous functionalized polymers enable generating and transporting hyperpolarized mixtures of metabolites

Hyperpolarization by dissolution dynamic nuclear polarization has brought highly sensitive magnetic resonance to reality but there still remains severe limitations. Here the authors show an approach relying on the generation of hyperpolarizing polymers that bear a dual function.

Théo El Daraï
Samuel F. Cousin
Sami Jannin
ResearchOpen Access04 Aug 2021
Nature Communications

Volume: 12, P: 1-9
Scientists blamed for olive-tree ruin

Police investigate researchers' role in devastating bacterial epidemic.
Italian scientists vilified in wake of olive-tree deaths

Alison Abbott
News01 Jun 2015
Nature

Volume: 522, P: 13-14
Microscopic manifestation of the spin phase transition at filling factor 2/3

Basile Verdene
Jens Martin
Amir Yacoby
Research15 Apr 2007
Nature Physics

Volume: 3, P: 392-396
Cannabidiol mitigates alcohol dependence and withdrawal with neuroprotective effects in the basolateral amygdala and striatum

Selen Dirik
Michelle R. Doyle
Giordano de Guglielmo
ResearchOpen Access10 Jul 2025
Neuropsychopharmacology

Volume: 51, P: 691-702
Impact and characterization of serial structural variations across humans and great apes

Structural variants (SV) can accumulate in repeat-rich parts of the genome and transform them in unexpected ways. Here, with their new assembly-based genotyper (NAHRwhals), the authors verify multi-step SVs in 37 human loci and identify alleles at risk for copy-number variation.

Wolfram Höps
Tobias Rausch
Fritz J. Sedlazeck
ResearchOpen Access13 Sept 2024
Nature Communications

Volume: 15, P: 1-15
Elevated dietary ω-6 polyunsaturated fatty acids induce reversible peripheral nerve dysfunction that exacerbates comorbid pain conditions

Boyd and LoCoco et al. link ω-6 polyunsaturated fatty acid–rich diet to development of peripheral nerve damage in mice, revealing diet as a risk factor for chronic pain.

Jacob T. Boyd
Peter M. LoCoco
Kenneth M. Hargreaves
Research17 Jun 2021
Nature Metabolism

Volume: 3, P: 762-773
Motor phenotype is not associated with vascular dysfunction in symptomatic Huntington’s disease transgenic R6/2 (160 CAG) mice

A. Di Pardo
A. Carrizzo
C. Vecchione
ResearchOpen Access17 Feb 2017
Scientific Reports

Volume: 7, P: 1-9
Random errors in protein synthesis activate an age-dependent program of muscle atrophy in mice

By introducing a ribosomal ambiguity mutation into mice, Moore et al. establish an in-vivo model to investigate how age-related diseases are related to decreasing accuracy in protein synthesis. Their findings potentially offer new insights into the pathological changes observed in age-related diseases, such as muscle atrophy

James Moore
Rashid Akbergenov
Erik C. Böttger
ResearchOpen Access08 Jun 2021
Communications Biology

Volume: 4, P: 1-11
Age- and sex-specific deterioration on bone and osteocyte lacuno-canalicular network in a mouse model of premature aging

Dilara Yılmaz
Francisco C. Marques
Ralph Müller
ResearchOpen Access23 May 2025
Bone Research

Volume: 13, P: 1-11

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