Katz and colleagues summarize knowledge on associations between drug pharmacokinetics and variations in genes coding for proteins involved in drug disposition. They propose a novel strategy in which pharmacogenetic data from early clinical studies is used both to feed back to furtherin vitrostudies of drug pharmacokinetics and to feed forward to optimize later-stage clinical trials, and discuss how this could improve drug development.
- David A. Katz
- Bernard Murray
- Leonardo Sahelijo
