The pathogenic relationship between bisphosphonates and osteonecrosis of the jaw is unclear, but there is evidence to indicate an association between high-dose bisphosphonate treatment and exposure to dental infections and oral surgical procedures. The authors of this Review highlight that a better knowledge of the interactions between these agents and of the jaw and maxillary bone biology will improve clinical and therapeutic approaches to osteonecrosis of the jaw.
- Francesco Bertoldo
- Daniele Santini
- Vincenzo Lo Cascio