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Showing 1–50 of 90 results

Advanced filters: Author: A Knopp Clear advanced filters

Towards a general-purpose foundation model for computational pathology

Pretrained using over 100,000 diagnostic histopathological slides across 20 major tissue types, a self-supervised model is shown to outperform existing baselines across various clinically relevant computational pathology tasks.

Richard J. Chen
Tong Ding
Faisal Mahmood
Research19 Mar 2024
Nature Medicine

Volume: 30, P: 850-862
Reproduction of the Viruses isolated from Cases of Infectious Hepatitis on Detroit-6(VA) Cell Line

J. LÁSZLÓ
E. BÁLINT
SUSANA ALMÁSI
Research17 Jul 1965
Nature

Volume: 207, P: 326-327
Evidence for at least four Fanconi anaemia genes including FACC on chromosome 9

Craig A. Strathdee
Alessandra M.V. Duncan
Manuel Buchwald
Research01 Jun 1992
Nature Genetics

Volume: 1, P: 196-198
Biological Molecules in their Excited States

J. EISINGER
A. A. LAMOLA
W. B. GRATZER
Research11 Apr 1970
Nature

Volume: 226, P: 113-118
Enhancing recall in asphalt pavement crack segmentation using a HoughNet-extended U-Net architecture with reconstruction head

István Reményi
Ámon Kiss
János Botzheim
ResearchOpen Access18 Dec 2025
Scientific Reports

Volume: 16, P: 1-14
Graph Fourier transform for spatial omics representation and analyses of complex organs

SpaGFT is a spatial omics representation method. It identifies spatially variable genes, enhances gene imputation, detects immunological regions, and characterises variations in secondary lymphoid organs. This method improves predictive power in wide downstream machine-learning tasks.

Yuzhou Chang
Jixin Liu
Qin Ma
ResearchOpen Access29 Aug 2024
Nature Communications

Volume: 15, P: 1-22
A Technique for the Measurement of Lead Tolerance in Plants

D. A. WILKINS
Research06 Jul 1957
Nature

Volume: 180, P: 37-38
Next-generation phenotyping integrated in a national framework for patients with ultrarare disorders improves genetic diagnostics and yields new molecular findings

Exome sequencing within a structured diagnostic process for rare diseases in Germany shows how facial image analysis and machine learning can guide variant prioritization and uncover many ultrarare diseases.

Axel Schmidt
Magdalena Danyel
Matias Wagner
ResearchOpen Access22 Jul 2024
Nature Genetics

Volume: 56, P: 1644-1653
Prediction of postoperative delirium after cardiac surgery by the interplay between preoperative plasma p-tau181 and IL-6 and heart-brain axis related factors: results from the prospective observational study FINDERI

Niels Hansen
Clara Maria Knopp
Theresa Maria Kruck
ResearchOpen Access22 Dec 2025
Molecular Psychiatry

P: 1-11
Cloning of cDNAs for Fanconi's anaemia by functional complementation

Craig A. Strathdee
Hanna Gavish
Manuel Buchwald
Research30 Apr 1992
Nature

Volume: 356, P: 763-767
Dominant variants in major spliceosome U4 and U5 small nuclear RNA genes cause neurodevelopmental disorders through splicing disruption

Analysis of snRNA genes in individuals with rare disorders identifies de novo and recurrent variants in RNU5B-1 and RNU5A-1, in addition to previously unreported cases with pathogenic or likely pathogenic variants in RNU4-2.

Caroline Nava
Benjamin Cogne
Christel Depienne
ResearchOpen Access16 May 2025
Nature Genetics

Volume: 57, P: 1374-1388
Uncovering nitroxoline activity spectrum, mode of action and resistance across Gram-negative bacteria

Nitroxoline is a bacteriostatic quinoline antibiotic, known to form complexes with metals, with few clinical applications. Here, Cacace et al. show that the compound displays a broad activity spectrum, with species-specific bactericidal activity, and acts as a metallophore inducing copper and zinc intoxication in bacterial cells.

Elisabetta Cacace
Manuela Tietgen
Stephan Göttig
ResearchOpen Access22 Apr 2025
Nature Communications

Volume: 16, P: 1-16
Photography under Water

P. A. SMITH
Reviews02 Apr 1971
Nature

Volume: 230, P: 311-312
Mathematical Series

T. A. A. BROADBENT
Reviews02 Apr 1971
Nature

Volume: 230, P: 310-311
Theophylline Stimulates Fetal Breathing Movements during Hypoxia

John M Bissonnette
Roger A Hohimer
Neil F Notoroberto
Research01 Aug 1990
Pediatric Research

Volume: 28, P: 83-86
Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism

Immunostimulatory antibodies have strong potential as anti-cancer therapeutics. Here Elliott et al. show that conformational rigidity determines agonistic activity of antibodies targeting CD40 and 4-1BB and demonstrate further enhancement of agonism through disulfide engineering.

Isabel G. Elliott
Hayden Fisher
Ivo Tews
ResearchOpen Access12 Apr 2025
Nature Communications

Volume: 16, P: 1-13
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Personality Structure as the Main Determinant of Drug Induced (Model) Psychoses

ROLAND FISCHER
PHILIP A. MARKS
MARSHA A. ROCKEY
Research20 Apr 1968
Nature

Volume: 218, P: 296-298
Author Correction: Next-generation phenotyping integrated in a national framework for patients with ultrarare disorders improves genetic diagnostics and yields new molecular findings

Axel Schmidt
Magdalena Danyel
Matias Wagner
Amendments and CorrectionsOpen Access24 Jun 2025
Nature Genetics

Volume: 57, P: 1790-1791
Treatment of hypercholesterolemia in patients with metabolic syndrome: how do different statins compare?

Robert H Knopp
Pathmaja Paramsothy
Comments & Opinion01 Mar 2006
Nature Clinical Practice Endocrinology & Metabolism

Volume: 2, P: 136-137
An X-ray free-electron laser with a highly configurable undulator and integrated chicanes for tailored pulse properties

Since their initial operation, free-electron lasers are regularly upgraded in their performance and parameter control. Here the authors present the first lasing results of the soft X-ray free-electron laser beamline of the Paul Scherrer Institute, demonstrating different modes of operation and polarisation control of the tailored soft X-ray pulses.

Eduard Prat
Andre Al Haddad
Tobias Weilbach
ResearchOpen Access21 Aug 2023
Nature Communications

Volume: 14, P: 1-11
Systematic analysis of drug combinations against Gram-positive bacteria

Antibacterial combinations that are potent against Gram-positive bacteria are identified using an automated high-throughput screen.

Elisabetta Cacace
Vladislav Kim
Athanasios Typas
ResearchOpen Access28 Sept 2023
Nature Microbiology

Volume: 8, P: 2196-2212
A cell-free biosensor signal amplification circuit with polymerase strand recycling

A signal amplification circuit based on recycling nucleic acid inputs with RNA polymerase off-target transcription improves the sensitivity of transcription factor-based cell-free biosensors, achieving 10-fold decreases in limits of detection.

Yueyi Li
Tyler Lucci
Julius B. Lucks
Research13 Jan 2025
Nature Chemical Biology

Volume: 21, P: 949-958
Impact of ezetimibe on plasma lipoprotein(a) concentrations as monotherapy or in combination with statins: a systematic review and meta-analysis of randomized controlled trials

Amirhossein Sahebkar
Luis E. Simental-Mendía
Stephen L. Atkin
ResearchOpen Access14 Dec 2018
Scientific Reports

Volume: 8, P: 1-9
Adult human kidney organoids originate from CD24⁺ cells and represent an advanced model for adult polycystic kidney disease

Adult kidney organoids, or tubuloids, originate from CD24⁺ epithelial cells. Tubuloids represent a functional kidney tubule and can be used to model autosomal dominant polycystic kidney disease and study drug response.

Yaoxian Xu
Christoph Kuppe
Rafael Kramann
Research27 Oct 2022
Nature Genetics

Volume: 54, P: 1690-1701
Vascular Lactic Acid Infusions Do Not Alter the Incidence of Fetal Breathing Movements or Their Inhibition by Acute Hypoxemia

A Roger Hohimer
John M Bissonnette
Research01 May 1991
Pediatric Research

Volume: 29, P: 483-486
Taking a snapshot of the triplet excited state of an OLED organometallic luminophore using X-rays

OLED materials based on thermally activated delayed fluorescence have promising efficiency. Here, the authors investigate an organometallic multicore Cu complex as luminophore, by pump-probe X-ray techniques at three different facilities deriving a complete picture of the charge transfer in the triplet excited state.

Grigory Smolentsev
Christopher J. Milne
Matthias Vogt
ResearchOpen Access01 May 2020
Nature Communications

Volume: 11, P: 1-9
Spectroscopic disentanglement of the quantum states of highly excited Cu₂

Transition metals are at the basis of key processes in chemistry and biology but their complex electronic structures make understanding of their properties a challenge. Here the authors resolve individual spectral lines of Cu₂ in the deep UV region by two-colour resonant four-wave mixing.

M. Beck
P. Bornhauser
P. P. Radi
ResearchOpen Access22 Jul 2019
Nature Communications

Volume: 10, P: 1-8
Diagnostic utility of DNA methylation analysis in genetically unsolved pediatric epilepsies and CHD2 episignature refinement

Aberrant changes in DNA methylation have been implicated in various neurodevelopmental disorders but remain under studied in developmental and epileptic encephalopathies. Here, the authors demonstrate the diagnostic utility of genome-wide DNA methylation analyses toward identifying molecular etiologies in developmental and epileptic encephalopathies.

Christy W. LaFlamme
Cassandra Rastin
Heather C. Mefford
ResearchOpen Access06 Aug 2024
Nature Communications

Volume: 15, P: 1-21
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Advanced stage classical Hodgkin lymphoma patients with a positive interim-PET (PET-2) Deauville score 5 after 2 ABVD cycles: a pooled analysis of three multicenter trials

Simonetta Viviani
Chiara Pavoni
Corrado Tarella
ResearchOpen Access16 Oct 2025
Blood Cancer Journal

Volume: 15, P: 1-9
Biallelic loss-of-function variants in WDR11 are associated with microcephaly and intellectual disability

Natja Haag
Ene-Choo Tan
Cordula Knopp
ResearchOpen Access20 Aug 2021
European Journal of Human Genetics

Volume: 29, P: 1663-1668
Experiences of predictive testing in young people at risk of Huntington’s disease, familial cardiomyopathy or hereditary breast and ovarian cancer

Rhona MacLeod
Anna Beach
Lauren Kerzin-Storrar
Research17 Jul 2013
European Journal of Human Genetics

Volume: 22, P: 396-401
Establishing nonlinearity thresholds with ultraintense X-ray pulses

Jakub Szlachetko
Joanna Hoszowska
Christopher J. Milne
ResearchOpen Access13 Sept 2016
Scientific Reports

Volume: 6, P: 1-7
How evolution builds genes from scratch

Scientists long assumed that new genes appear when evolution tinkers with old ones. It turns out that natural selection is much more creative.

Adam Levy
News16 Oct 2019
Nature

Volume: 574, P: 314-316
Heme processing in the malaria parasite, Plasmodium falciparum: a time-dependent basal-level analysis

Digestive vacuole uptake and growth, plasmepsin abundance and basal levels of hemoglobin, heme and hemozoin in Plasmodium falciparum reveal native state parasite physiology as having three distinct developmental phases with specific characteristics.

Larnelle F. Garnie
Timothy J. Egan
Kathryn J. Wicht
ResearchOpen Access13 Nov 2025
Communications Biology

Volume: 8, P: 1-15
Visualization of spatial and temporal temperature distributions with magnetic particle imaging for liver tumor ablation therapy

J. Salamon
J. Dieckhoff
H. Ittrich
ResearchOpen Access04 May 2020
Scientific Reports

Volume: 10, P: 1-11
Association of essential hypertension in elderly Japanese with I/D polymorphism of the angiotensin-converting enzyme (ACE) gene

K. Yoshida
T. Ishigami
S. Umemura
Research01 Sept 2000
Journal of Human Genetics

Volume: 45, P: 294-298
Modeling transmission mechanism to infer treatment efficacy of different drugs and combination therapy against Trichuris trichiura

Carla M. Grolimund
Jürg Utzinger
Penelope Vounatsou
ResearchOpen Access09 Oct 2024
Scientific Reports

Volume: 14, P: 1-9
Quantitative imaging of tumour blood flow by contrast-enhanced magnetic resonance imaging

S Pahernik
J Griebel
A E Goetz
ResearchOpen Access27 Nov 2001
British Journal of Cancer

Volume: 85, P: 1655-1663
SPRING, an effective and reliable framework for image reconstruction in single-particle Coherent Diffraction Imaging

Alessandro Colombo
Mario Sauppe
Daniela Rupp
ResearchOpen Access19 Aug 2025
npj Computational Materials

Volume: 11, P: 1-23
Erratum: Targeting BRAF in thyroid cancer

A V Espinosa
L Porchia
M D Ringel
Amendments and CorrectionsOpen Access17 Apr 2007
British Journal of Cancer

Volume: 96, P: 1313
Genome-wide mapping and analysis of chromosome architecture

The three-dimensional (3D) organization of eukaryote chromosomes regulates genome function and nuclear processes such as DNA replication, transcription and DNA-damage repair. Experimental and computational methodologies for 3D genome analysis have been rapidly expanding, with a focus on high-throughput chromatin conformation capture techniques and on data analysis.

Anthony D. Schmitt
Ming Hu
Bing Ren
Reviews01 Sept 2016
Nature Reviews Molecular Cell Biology

Volume: 17, P: 743-755
Design of an alternate antibody fragment format that can be produced in the cytoplasm of Escherichia coli

Aatir A. Tungekar
Lloyd W. Ruddock
ResearchOpen Access30 Aug 2023
Scientific Reports

Volume: 13, P: 1-10
Genetical variation for enzyme activity in a population of Drosophila melanogaster

A J Birley
B W Barnes
Research01 Aug 1975
Heredity

Volume: 35, P: 121-126
Author Correction: Hard X-ray transient grating spectroscopy on bismuth germanate

Jérémy R. Rouxel
Danny Fainozzi
Cristian Svetina
Amendments and Corrections11 May 2021
Nature Photonics

Volume: 15, P: 712
Development of a subsurface LIBS sensor for in situ groundwater quality monitoring with applications in CO₂ leak sensing in carbon sequestration

D. A. Hartzler
J. C. Jain
D. L. McIntyre
ResearchOpen Access14 Mar 2019
Scientific Reports

Volume: 9, P: 1-10
Proximal, Tracheal, and Alveolar Pressures during High-Frequency Oscillatory Ventilation in a Normal Rabbit Model

Dale R Gerstmann
Janie M Fouke
Robert A deLemos
Research01 Oct 1990
Pediatric Research

Volume: 28, P: 367-373
Heterogeneous spectrum of mutations in the Fanconi anaemia group A gene

M Wijker
NV Morgan
CG Mathew
Research12 Mar 1999
European Journal of Human Genetics

Volume: 7, P: 52-59
Functional Magnetic Resonance Imaging Brain Mapping in Psychiatry: Methodological Issues Illustrated in a Study of Working Memory in Schizophrenia

Joseph H Callicott
Nicolas F Ramsey
Daniel R Weinberger
Research01 Mar 1998
Neuropsychopharmacology

Volume: 18, P: 186-196

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