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Showing 1–9 of 9 results
Advanced filters: Author: A Nordenfelt Clear advanced filters

  • The role of force in activating integrin cell adhesion receptors is not known. Here the authors develop fluorescent tension sensors for αL and β2 integrins and show that in migrating T cells force is transduced across the β2 integrin, and that this correlates with an active conformational state.

    • Pontus Nordenfelt
    • Hunter L. Elliott
    • Timothy A. Springer
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-15

  • Integrin αβ heterodimer cell surface receptors mediate adhesive interactions that provide traction for cell migration. Here the authors show that actin flow can orient cell surface integrins during leukocyte migration, suggesting integrin activation by cytoskeletal force.

    • Pontus Nordenfelt
    • Travis I. Moore
    • Timothy A. Springer
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16

  • Ancient DNA reveals how the explosive expansion of Yamnaya steppe pastoralists began with a small community north of the Black Sea speaking ancestral Indo-European, and detects genetic links with Anatolian speakers, stemming from a common Indo-Anatolian homeland in the North Caucasus–lower Volga region.

    • Iosif Lazaridis
    • Nick Patterson
    • David Reich
    Research
    Nature
    Volume: 639, P: 132-142

  • Deep whole-genome sequencing of 300 individuals from 142 diverse populations provides insights into key population genetic parameters, shows that all modern human ancestry outside of Africa including in Australasians is consistent with descending from a single founding population, and suggests a higher rate of accumulation of mutations in non-Africans compared to Africans since divergence.

    • Swapan Mallick
    • Heng Li
    • David Reich
    Research
    Nature
    Volume: 538, P: 201-206

  • A sequencing study comparing ancient and contemporary genomes reveals that most present-day Europeans derive from at least three highly differentiated populations: west European hunter-gatherers, ancient north Eurasians (related to Upper Palaeolithic Siberians) and early European farmers of mainly Near Eastern origin.

    • Iosif Lazaridis
    • Nick Patterson
    • Johannes Krause
    Research
    Nature
    Volume: 513, P: 409-413

  • A genome-wide analysis of 69 ancient Europeans reveals the history of population migrations around the time that Indo-European languages arose in Europe, when there was a large migration into Europe from the Eurasian steppe in the east (providing a genetic ancestry still present in Europeans today); these findings support a ‘steppe origin’ hypothesis for how some Indo-European languages arose.

    • Wolfgang Haak
    • Iosif Lazaridis
    • David Reich
    Research
    Nature
    Volume: 522, P: 207-211