The suppressive function and number of regulatory T cells (Treg cells) is reduced in autoimmune disease. Here, Giuseppe Matarese and colleagues report that Treg cell proliferation is reduced in subjects with relapsing-remitting multiple sclerosis. As disease severity increases, Treg cell proliferation progressively decreases and is associated with impaired IL-2 release and IL-2 receptor and mTOR signaling.
- Fortunata Carbone
- Veronica De Rosa
- Giuseppe Matarese