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Showing 1–19 of 19 results

Advanced filters: Author: A Skowronska Clear advanced filters

Assassins of eyesight

A molecular cascade involving the transcription factor SIX6 and its target gene p16INK4a causes the death of neurons that link the eye to the brain. This discovery deepens our understanding of a common form of blindness, glaucoma.

Andrew D. Huberman
Rana N. El-Danaf
News & Views25 Nov 2015
Nature

Volume: 527, P: 456-457
An Rh Antibody Specific for V and R′^s

RUTH SANGER
JEAN NOADES
C. A. CUNNINGHAM
Research09 Apr 1960
Nature

Volume: 186, P: 171
Range extender mediates long-distance enhancer activity

The REX element is associated with long-range enhancer–promoter interactions.

Grace Bower
Ethan W. Hollingsworth
Evgeny Z. Kvon
ResearchOpen Access02 Jul 2025
Nature

Volume: 643, P: 830-838
Self-amplifying NRF2–EZH2 epigenetic loop converts KRAS-initiated progenitors to invasive pancreatic cancer

Using pancreatic organoids and genetic mouse models, Antonucci et al. show that cellular stress activates an NRF2–EZH2 epigenetic axis leading to metabolic reprogramming and subsequent malignant transformation of KRAS-mutant benign lesions.

Laura Antonucci
Na Li
Michael Karin
Research30 Jun 2025
Nature Cancer

Volume: 6, P: 1263-1282
Multi-molecular hyperspectral PRM-SRS microscopy

Spatial imaging methods in lipid research can disrupt tissue integrity and can have limited spatial and spectral resolution. Here, the authors present an SRS-based hyperspectral imaging platform to visualise lipids and lipoproteins in a variety of tissues and animal species.

Wenxu Zhang
Yajuan Li
Lingyan Shi
ResearchOpen Access21 Feb 2024
Nature Communications

Volume: 15, P: 1-14
Super-resolution SRS microscopy with A-PoD

Adam optimization-based pointillism deconvolution (A-PoD) is a broadly applicable super-resolution deconvolution algorithm. A-PoD-coupled SRS microscopy reveals heterogeneous metabolic activity in subcellular structures like lipid droplets.

Hongje Jang
Yajuan Li
Lingyan Shi
Research16 Feb 2023
Nature Methods

Volume: 20, P: 448-458
Lens regeneration using endogenous stem cells with gain of visual function

A new procedure for cataract removal that preserves lens epithelial progenitor cells in mammals, which require Pax6 and Bmi1 for their self-renewal, achieves lens regeneration in rabbits, macaques and in infants with cataracts.

Haotian Lin
Hong Ouyang
Yizhi Liu
Research09 Mar 2016
Nature

Volume: 531, P: 323-328
Safer and efficient base editing and prime editing via ribonucleoproteins delivered through optimized lipid-nanoparticle formulations

The safety and efficacy of ribonucleoproteins for genome editing can be enhanced by formulations of lipid nanoparticles optimized for enhanced stability, delivery efficiency and editing potency of the protein complexes.

Rafał Hołubowicz
Samuel W. Du
Krzysztof Palczewski
ResearchOpen Access28 Nov 2024
Nature Biomedical Engineering

Volume: 9, P: 57-78
Evaluating the neuroprotective impact of senolytic drugs on human vision

Nevin W. El-Nimri
Spencer M. Moore
Sally L. Baxter
ResearchOpen Access10 Dec 2020
Scientific Reports

Volume: 10, P: 1-8
Required enhancer–matrin-3 network interactions for a homeodomain transcription program

The POU homeodomain transcription factor Pit1 is required for pituitary development; here Pit1-occupied enhancers are shown to interact with the nuclear architecture components matrin-3 and Satb1, and this association is required for activation of Pit1-regulated enhancers and coding target genes.

Dorota Skowronska-Krawczyk
Qi Ma
Michael G. Rosenfeld
Research03 Aug 2014
Nature

Volume: 514, P: 257-261
Correction: Corrigendum: Lens regeneration using endogenous stem cells with gain of visual function

Haotian Lin
Hong Ouyang
Yizhi Liu
Amendments and Corrections30 Nov 2016
Nature

Volume: 541, P: 558
Serum metabolomics indicates ferroptosis in patients with pantothenate kinase associated neurodegeneration

Beata Toczylowska
Marta Skowronska
Elzbieta Zieminska
ResearchOpen Access20 Mar 2025
Scientific Reports

Volume: 15, P: 1-14
In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration

A method for CRISPR-based genome editing that harnesses cellular non-homologous end joining activity to achieve targeted DNA knock-in in non-dividing tissues.

Keiichiro Suzuki
Yuji Tsunekawa
Juan Carlos Izpisua Belmonte
Research16 Nov 2016
Nature

Volume: 540, P: 144-149
Loss of AKAP1 triggers Drp1 dephosphorylation-mediated mitochondrial fission and loss in retinal ganglion cells

Genea Edwards
Guy A. Perkins
Won-Kyu Ju
ResearchOpen Access20 Apr 2020
Cell Death & Disease

Volume: 11, P: 1-15
A European Multi Lake Survey dataset of environmental variables, phytoplankton pigments and cyanotoxins

Evanthia Mantzouki
James Campbell
Bastiaan W. Ibelings
ResearchOpen Access23 Oct 2018
Scientific Data

Volume: 5, P: 1-13
A novel functional assay using etoposide plus nutlin-3a detects and distinguishes between ATM and TP53 mutations in CLL

O G Best
A C Gardiner
D G Oscier
Correspondence17 Jan 2008
Leukemia

Volume: 22, P: 1456-1459
Assessment of p53 and ATM functionality in chronic lymphocytic leukemia by multiplex ligation-dependent probe amplification

G D te Raa
P D Moerland
A P Kater
ResearchOpen Access06 Aug 2015
Cell Death & Disease

Volume: 6, P: e1852
The impact of SF3B1 mutations in CLL on the DNA-damage response

G D te Raa
I A M Derks
E Eldering
Research05 Nov 2014
Leukemia

Volume: 29, P: 1133-1142
Preschool children blood pressure percentiles by age and height

A Grajda
Z Kułaga
M Litwin
Research29 Dec 2016
Journal of Human Hypertension

Volume: 31, P: 400-408