Telomeres protect chromosomes from degradation and are therefore essential for ensuring genomic stability. These heterochromatic structures are bound by the shelterin complex, which regulates the activity of telomerase at the ends of chromosomes. This Review analyses the role of these telomeric proteins in cancer and ageing through modulating telomere length and protection, as well as through their 'extracurriculum' activities as gene expression regulators by binding to non-telomeric sites.
- Paula Martínez
- María A. Blasco
