Nature Search

Fusion brings down barriers

It remains uncertain how tissue-specific stem cells could generate the mature cell types of another tissue. In one instance, where bone-marrow-derived stem cells repair damaged liver in mice, cell fusion is the answer.

Alexander Medvinsky
Austin Smith
News & Views24 Apr 2003
Nature

Volume: 422, P: 823-825
Are TNF blockers safe for patients with hepatitis B virus infection?

Immunosuppression has been associated with viral reactivation in patients with chronic viral infections. A prospective study has concluded that it is safe to use anti-tumor-necrosis-factor agents in patients with chronic hepatitis B virus infection receiving antiviral prophylaxis. Is there sufficient evidence to back up this conclusion?

Manuel Ramos-Casals
News & Views29 Oct 2010
Nature Reviews Rheumatology

Volume: 6, P: 618-620
ATG16L1 induces the formation of phagophore-like membrane cups

Autophagy degrades cellular waste by engulfing it in phagophore membranes and delivering it to lysosomes for degradation. Here Mohan and colleagues identified a type of membrane coat that assembles on phagophores to guide their expansion.

Jagan Mohan
Satish B. Moparthi
Thomas Wollert
Research04 Jun 2024
Nature Structural & Molecular Biology

Volume: 31, P: 1448-1459
Cytochrome P450 enzyme polymorphisms and treatment-related ovarian toxicity in patients with SLE

Dimitrios Vassilopoulos
Comments & Opinion07 Aug 2007
Nature Clinical Practice Rheumatology

Volume: 3, P: 492-493
Ultrastructure of the axonal periodic scaffold reveals a braid-like organization of actin rings

The ultrastructural details of the periodic scaffold of actin rings under the plasma membrane of axons remain unknown. Here, the authors combine platinum-replica electron and optical super-resolution microscopy and resolve actin rings as braids made of two long, intertwined actin filaments connected by a dense mesh of aligned spectrins.

Stéphane Vassilopoulos
Solène Gibaud
Christophe Leterrier
ResearchOpen Access20 Dec 2019
Nature Communications

Volume: 10, P: 1-13
Minichromosome maintenance proteins 2 and 5 in non-benign epithelial ovarian tumours: relationship with cell cycle regulators and prognostic implications

H Gakiopoulou
P Korkolopoulou
E Patsouris
ResearchOpen Access16 Oct 2007
British Journal of Cancer

Volume: 97, P: 1124-1134
MT1-MMP directs force-producing proteolytic contacts that drive tumor cell invasion

The mechanism of force production by invadopodia is unclear. Here, the authors show that cell surface MT1-MMP when in contact with collagen, induces Arp2/3 branched actin polymerisation on the concave side of invadopodia, which generates a pushing force along with collagen cleavage by MT1-MMP to invade.

Robin Ferrari
Gaëlle Martin
Philippe Chavrier
ResearchOpen Access25 Oct 2019
Nature Communications

Volume: 10, P: 1-15
A novel assay for screening patients for latent tuberculosis infection prior to anti-TNF therapy

Kevin L Winthrop
Charles L Daley
Comments & Opinion22 Jul 2008
Nature Clinical Practice Rheumatology

Volume: 4, P: 456-457
Cryo-electron tomography pipeline for plasma membranes

Cryo-electron tomography requires thin samples. Few cell-thinning techniques have been standardized. Here, the authors provide and validate a method to prepare, label, and image proteins at mammalian cell plasma membranes for sub-nanometer structural analysis.

Willy W. Sun
Dennis J. Michalak
Justin W. Taraska
ResearchOpen Access20 Jan 2025
Nature Communications

Volume: 16, P: 1-14
Preventing and treating biologic-associated opportunistic infections

Owing to the critical role of tumor necrosis factor in host immunity, patients receiving tumor necrosis factor inhibitors for the treatment of autoimmune disorders are at significantly increased risk of infection from a variety of pathogens. The authors review the evidence and provide expert opinion on how best to prevent opportunistic infections in this setting.

Kevin L. Winthrop
Tom Chiller
Reviews01 Jul 2009
Nature Reviews Rheumatology

Volume: 5, P: 405-410
Microtubules tune mechanosensitive cell responses

Substrate-rigidity-dependent microtubule acetylation is now shown to be triggered by mechanosensing at focal adhesions, and in turn controls the mechanosensitivity of Yes-associated protein (YAP) translocation, focal adhesion distribution, actomyosin contractility and cell migration.

Shailaja Seetharaman
Benoit Vianay
Sandrine Etienne-Manneville
Research18 Oct 2021
Nature Materials

Volume: 21, P: 366-377
Management of rheumatic disease with comorbid HBV or HCV infection

Chronic infection with hepatitis B virus (HBV) or hepatitis C virus (HCV) is a global health problem. Management of patients with co-existing rheumatic disease and viral hepatitis can be challenging, given that immunosuppressive and biologic agents used to treat rheumatic disease can have serious complications. This Review provides a guide to viral hepatitis for the rheumatologist, describing the characteristics, complications and treatment of chronic HBV or HCV infection in rheumatic disease.

Dimitrios Vassilopoulos
Leonard H. Calabrese
Reviews08 May 2012
Nature Reviews Rheumatology

Volume: 8, P: 348-357
Dual clathrin and integrin signaling systems regulate growth factor receptor activation

The integration and organization of growth factor signaling, adhesion, and endocytosis is poorly understood. Here the authors use light and electron microscopy to shed light on the role of flat clathrin lattices and cell adhesion in growth factor signaling.

Marco A. Alfonzo-Méndez
Kem A. Sochacki
Justin W. Taraska
ResearchOpen Access16 Feb 2022
Nature Communications

Volume: 13, P: 1-16
The nanoscale molecular morphology of docked exocytic dense-core vesicles in neuroendocrine cells

The molecular organization of exocytic vesicles regulates their transport and fusion. Prasai, Taraska, and colleagues use correlative light and electron microscopy, along with 3D tomography and gold labeling, to directly map proteins on single exocytic organelles at the plasma membrane.

Bijeta Prasai
Gideon J. Haber
Justin W. Taraska
ResearchOpen Access25 Jun 2021
Nature Communications

Volume: 12, P: 1-14
Foamy virus vectors: The usefulness of a perfect parasite

G Vassilopoulos
A Rethwilm
News14 Aug 2008
Gene Therapy

Volume: 15, P: 1299-1301
APOLIPOPROTEIN E ε4 ALLELE AS A RISK FACTOR FOR LEFT VENTRICULAR FAILURE IN β-THALASSAEMIA HOMOZYGOTES. 97

E Economou-Petersen
M Karagiorga-Lagana
M B Petersen
Research01 May 1997
Pediatric Research

Volume: 41, P: 763
Biological implications of cell fusion

Brenda M. Ogle
Marilia Cascalho
Jeffrey L. Platt
Reviews15 Jun 2005
Nature Reviews Molecular Cell Biology

Volume: 6, P: 567-575
A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain

Necroptosis drives arthritis. Polykratis et al. show that the deubiquitinating enzyme A20 inhibits inflammasome-dependent arthritis development by regulating macrophage necroptosis and this function depends on its ZnF7 ubiquitin binding domain.

Apostolos Polykratis
Arne Martens
Manolis Pasparakis
Research13 May 2019
Nature Cell Biology

Volume: 21, P: 731-742
Vinegar reduces postprandial hyperglycaemia in patients with type II diabetes when added to a high, but not to a low, glycaemic index meal

S Liatis
S Grammatikou
N Katsilambros
Research26 May 2010
European Journal of Clinical Nutrition

Volume: 64, P: 727-732
Versatile tethering system to control cell-specific targeting of bioengineered extracellular vesicles

Sheryl Bui
Jeanne Lainé
Gregory Lavieu
ResearchOpen Access03 Jun 2025
Scientific Reports

Volume: 15, P: 1-12
Adjuvant chemotherapy for oesophagogastric cancer with epirubicin, cisplatin and infusional 5-fluorouracil (ECF): a Royal Marsden pilot study

A Bamias
D Cunningham
A Hill
Research01 Mar 1995
British Journal of Cancer

Volume: 71, P: 583-586
A TNFR2 3′ flanking region polymorphism in systemic lupus erythematosus

KE Sullivan
LM Piliero
MA Petri
Research08 Feb 2000
Genes & Immunity

Volume: 1, P: 225-227
Misregulated alternative splicing of BIN1 is associated with T tubule alterations and muscle weakness in myotonic dystrophy

Myotonic dystrophy is a slowly progressing muscle disease marked by muscle wasting and myotonia. Nicolas Charlet-Berguerand and his colleagues have found that the myotonia component of the disease is probably due to missplicing of BIN1 RNA, resulting in malformation of T tubules in skeletal muscle and disruption of the excitation-contraction coupling machinery.

Charlotte Fugier
Arnaud F Klein
Nicolas Charlet-Berguerand
Research29 May 2011
Nature Medicine

Volume: 17, P: 720-725
The place of chemotherapy in the treatment of early breast cancer

A Buzdar
Research01 Jan 1998
British Journal of Cancer

Volume: 78, P: 16-20
The effect of vasopressin and hepatic artery ligation on the blood supply to normal and metastatic liver tissue

S A Jenkins
D W Day
R Shields
Research01 Dec 1984
British Journal of Cancer

Volume: 50, P: 785-791
Prenatal testing for Huntington's disease: a European collaborative study

Sheila A Simpson
Moniek W Zoeteweij
Gerry Evers-Kiebooms
Research29 Oct 2002
European Journal of Human Genetics

Volume: 10, P: 689-693
S100A8/A9 predicts response to PIM kinase and PD-1/PD-L1 inhibition in triple-negative breast cancer mouse models

Begg et al. show that S100A8/9 expression is associated with risk of progression in early-stage triple-negative breast cancer cohorts. Using a small inhibitor screen, the authors identify PIM kinase inhibitors to target S100A8/A9 expression, improving antitumor response when combined with immune checkpoint blockade in mice.

Lauren R. Begg
Adrienne M. Orriols
Dai Horiuchi
ResearchOpen Access20 Feb 2024
Communications Medicine

Volume: 4, P: 1-17
A critical role of CD29 and CD49f in mediating metastasis for cancer-initiating cells isolated from a Brca1-associated mouse model of breast cancer

A Vassilopoulos
C Chisholm
C-X Deng
Research09 Dec 2013
Oncogene

Volume: 33, P: 5477-5482
A phase II study of sequential 5-fluorouracil, epirubicin and cyclophosphamide (FEC) and paclitaxel in advanced breast cancer (Protocol PV BC 97/01)

A Riccardi
P Pugliese
C Tinelli
ResearchOpen Access17 Jul 2001
British Journal of Cancer

Volume: 85, P: 141-146
Polymorphisms and haplotypes in TLR9 and MYD88 are associated with the development of Hodgkin's lymphoma: a candidate–gene association study

Vassiliki Mollaki
Thomas Georgiadis
George Vassilopoulos
Research11 Sept 2009
Journal of Human Genetics

Volume: 54, P: 655-659
Codon 89 polymorphism in the human 5α-reductase gene in primary breast cancer

A Scorilas
B Bharaj
E P Diamandis
ResearchOpen Access20 Mar 2001
British Journal of Cancer

Volume: 84, P: 760-767
Origin of nondisjunction in trisomy 8 and trisomy 8 mosaicism

Georgia Karadima
Merete Bugge
Michael B Petersen
Research18 Nov 1998
European Journal of Human Genetics

Volume: 6, P: 432-438
Adherence to an intensive antihypertensive follow-up programme

E J Diamantopoulos
E A Andreadis
N H Tsiftsis
Research23 May 2003
Journal of Human Hypertension

Volume: 17, P: 437-439
HLA phenotypes as promoters of cardiovascular remodelling in subjects with arterial hypertension

E J Diamantopoulos
E A Andreadis
C A Papasteriades
Research13 Jan 2003
Journal of Human Hypertension

Volume: 17, P: 63-68
High-dose monotherapy vs low-dose combination therapy of calcium channel blockers and angiotensin receptor blockers in mild to moderate hypertension

E A Andreadis
G I Tsourous
E J Diamantopoulos
Research10 Mar 2005
Journal of Human Hypertension

Volume: 19, P: 491-496
Toxic iron species in lower-risk myelodysplastic syndrome patients: course of disease and effects on outcome

Marlijn Hoeks
Tim Bagguley
L. Bond
ResearchOpen Access18 Sept 2020
Leukemia

Volume: 35, P: 1745-1750
Cell death by mitotic catastrophe: a molecular definition

Maria Castedo
Jean-Luc Perfettini
Guido Kroemer
Reviews12 Apr 2004
Oncogene

Volume: 23, P: 2825-2837
Diagnostic criteria for systemic lupus erythematosus: has the time come?

Systemic lupus erythematosus (SLE) is a heterogeneous condition characterized by a wide range of symptoms, rendering its diagnosis an often difficult task. In this article, the authors highlight the current approaches and challenges in SLE diagnosis, propose an algorithm to facilitate this process, and argue for the development of endorsed diagnostic criteria.

George K. Bertsias
Cristina Pamfil
Dimitrios T. Boumpas
Reviews09 Jul 2013
Nature Reviews Rheumatology

Volume: 9, P: 687-694
ATM-deficiency increases genomic instability and metastatic potential in a mouse model of pancreatic cancer

Yiannis Drosos
David Escobar
Beatriz Sosa-Pineda
ResearchOpen Access11 Sept 2017
Scientific Reports

Volume: 7, P: 1-14
Estimation of the Mutation Frequencies in Charcot-Marie-Tooth Disease Type 1 and Hereditary Neuropathy with Liability to Pressure Palsies: A European Collaborative Study

Eva Nelis
Christine Van Broeckhoven
A. Gal
Research01 Jan 1996
European Journal of Human Genetics

Volume: 4, P: 25-33
Genetic instability and mammary tumor formation in mice carrying mammary-specific disruption of Chk1 and p53

T Fishler
Y-Y Li
C-X Deng
Research17 May 2010
Oncogene

Volume: 29, P: 4007-4017
WEE1 murine deficiency induces hyper-activation of APC/C and results in genomic instability and carcinogenesis

A Vassilopoulos
Y Tominaga
C-X Deng
Research04 Aug 2014
Oncogene

Volume: 34, P: 3023-3035
Dual transgene expression by foamy virus vectors carrying an endogenous bidirectional promoter

A Andrianaki
E K Siapati
G Vassilopoulos
Research12 Nov 2009
Gene Therapy

Volume: 17, P: 380-388
Rapid detection of MYD88-L265P mutation by PCR-RFLP in B-cell lymphoproliferative disorders

N Argentou
G Vassilopoulos
M Speletas
Correspondence18 Oct 2013
Leukemia

Volume: 28, P: 447-449
Going beyond established model systems of Alzheimer’s disease: companion animals provide novel insights into the neurobiology of aging

In this Perspective, the authors illustrate how the use of companion animal models will provide insight into of the neurobiology of aging.

Alexandra A. de Sousa
Brier A. Rigby Dames
Christine J. Charvet
ReviewsOpen Access21 Jun 2023
Communications Biology

Volume: 6, P: 1-16

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