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Random lasers do not have mirrors or optical elements. They often lack a well-defined shape or size, and their emission wavelength is difficult to tune. Now it is shown that the optical resonances in an ensemble of microspheres can provide the crucial element of control.

Identifying jets originating from heavy quarks plays a fundamental role in hadronic collider experiments. In this work, the ATLAS Collaboration describes and tests a transformer-based neural network architecture for jet flavour tagging based on low-level input and physics-inspired constraints.

Here the authors present a computational method that expands the potential of multimodal single-cell analyses by delivering an accurate, fast, and user-friendly approach for normalizing and comparing surface protein expression across large and heterogeneous datasets.

Here authors show loss of AKAP11, a strong genetic risk factor for bipolar disorder and schizophrenia, disrupts PKA proteostasis and signaling, leading to widespread transcriptomic alterations across the brain, particularly in striatal neurons, as well as altered behavior.

Relapsed and/or refractory acute myeloid leukemia (AML) postallogeneic hematopoietic cell transplantation has limited treatment options. Here the authors report the clinical results and immune correlates of a phase I/II trial of adoptively transferred virus-specific donor CD8 + T cells engineered to express a WT1-specific T cell receptor in patients with acute myeloid leukemia and active disease post-allogeneic hematopoietic cell transplantation.

Dinosaurs originated ~245 million years ago (mya) but did not diversify until some time in the Late Triassic. Here, Bernardi and colleagues synthesize palaeontological and dated stratigraphic evidence to show that dinosaur diversification followed the Carnian Pluvial Episode 234–232 mya.

In the observational ZERO Childhood Cancer Precision Medicine Program PRecISion Medicine for Children with Cancer (PRISM) trial, children with high-risk cancer were treated with molecular tumor board-recommended therapies, resulting in overall clinical response rates that translated into survival benefit after long-term follow-up.

Edward C. Holmes welcomes a robust account of how viruses emerge and how pandemics can be prevented.

In a phase 2 trial, the oral type II RAF inhibitor tovorafenib exhibited an overall response rate of 67% in patients with BRAF-altered relapsed/refractory pediatric low-grade glioma.

The struggle to find a theory of the weak nuclear force reveals intriguing personalities, finds Edwin Cartlidge.

Transcriptomics is widely used to identify functional and developmental states of T cells and their genetically engineered therapeutic counterparts, such as CAR-T cells. Here authors show that by looking at epigenetic markers in human CD8 + T cells and CAR-T cells, properties and quality of these cells, which are not obvious from gene expression analysis, could be accurately described.

Artificial intelligence holds great promise to improve diagnosis of numerous immune-related or infectious diseases. Here, the authors show that machine learning can be used to identify HIV-1 specific broad neutralising antibody.

Pedro Ferreira explores Alan Lightman's latest novel — a magical-reality take on the origins of the Universe.

Jacek Debiec enjoys two complementary books charting the psychology and neuroscience of decision-making.

BayesSpace increases the resolution of spatial transcriptomics by using neighborhood information.

The authors report a particle-particle correlation and velocity-difference profile method to measure nuclear lifetime. The results obtained for excited states of 23Mg are used to constrain the production of 22Na in the astrophysical novae explosions.

The RV144 vaccine trial showed reduced risk of HIV-1 acquisition, but mechanisms underlying protection are poorly understood. Here, Fourati et al. assess the transcriptomic profile of blood collected from 223 vaccinees and 40 placebo recipients and identify IRF7 as a mediator of protection.

Germline mutations in the Elongator complex gene ELP1 predispose individuals to the development of childhood medulloblastoma.

Understanding factors that impact CAR T cell expansion in the clinic is crucial to improving its therapeutic success. Here the authors document heterogeneity in the clonal dynamics of CAR-T cells by tracking individual clones using the endogenous TCR and integration sites and provide further insights into the role of transcriptional states in clonal kinetics.

Entanglement was observed in top–antitop quark events by the ATLAS experiment produced at the Large Hadron Collider at CERN using a proton–proton collision dataset with a centre-of-mass energy of √s  = 13 TeV and an integrated luminosity of 140 fb⁻¹.

γ-ray spectroscopy experiments on the origin of spin in the products of nuclear fission of spin-zero nuclei suggest that the fission fragments acquire their spin after scission, rather than before.

Pulendran and colleagues perform a comparative analysis of transcriptional responses of healthy young adults across 13 different vaccines. They find that while a common transcriptional program is shared across many vaccines, there is significant heterogeneity especially in the kinetics of immune responses.

The Zero Childhood Cancer pediatric precision medicine program informs treatment recommendations for children with high-risk cancers through comprehensive molecular profiling

An online approach for the DNA methylation-based classification of central nervous system tumours across all entities and age groups has been developed to help to improve current diagnostic standards.

The analysis of multiple SIV vaccine regimens in macaques leads to the identification of a key two-amino-acid signature that confers resistance to neutralizing antibodies; a similar mechanism of immune escape is shown to operate in HIV and may explain the limited efficacy seen in HIV vaccine trials.

Centrioles and cilia are microtubule-based structures of defined architecture, but what regulates this architecture is not clear. Here the authors discover that centrosomal-P4.1-associated-protein (CPAP) binds the α/β-tubulin dimer and licenses it for tubulin delivery contributing to centriolar/ciliary length and architecture control.

Measurements of the half-life and decay energy of the β-decay of ¹⁰⁰Sn show that Gamow–Teller transitions of this nucleus have the greatest strength found so far and are ‘superallowed’.

Most clinical trials of chemotherapeutics for advanced bladder cancer have shown limited benefits, so new prognostic markers and effective treatment strategies are necessary. Yoshino et al. discuss the microRNAs that have been identified as potential oncogenes or tumour suppressors, as well as those that have been implicated as prognostic biomarkers, in bladder cancer.

A spectroscopic study of ⁷⁸Ni confirms its doubly magic nature and reveals it as a stronghold beyond which the magic numbers 28 and 50 break down because of competing deformation.

The ATLAS Collaboration reports the observation of the electroweak production of two jets and a Z-boson pair. This process is related to vector-boson scattering and allows the nature of electroweak symmetry breaking to be probed.

Acquired resistance is a major problem in cancer immunotherapy. Here the authors report a study of two patients with Merkel cell carcinoma under immunotherapy treatment who develop resistance after deep responses for >1 year and identified a novel mechanism of acquired, gene-specific transcriptional suppression of HLAs.

Squidpy enables comprehensive analysis and visualization of spatial omics data and image with high efficiency.

The ATLAS experiment at the Large Hadron Collider reports a search for charged-lepton-flavour violation in decays of Z bosons into a τ lepton and an electron or muon of opposite charge.

The ATLAS Collaboration reports a measurement of the ratio of the decay rates of W bosons to τ leptons and muons, in agreement with universal lepton couplings as postulated in the standard model of particle physics.

Centriole duplication requires the loading of centriolar proteins to the daughter centriole during mitosis. Fu and colleagues analyse by 3D-structural illumination microscopy the sequential recruitment of centriolar proteins Cep135, Cep295 and Cep152.

CellCharter is a flexible, platform-agnostic method for identifying cell niches in spatially resolved data. Analysis of lung cancers demonstrates the importance of considering spatial information, exemplified by a neutrophil-associated niche that correlates with an aggressive cancer cell state and patient prognosis.

Ten years after the discovery of the Higgs boson, the ATLAS  experiment at CERN probes its kinematic properties with a significantly larger dataset from 2015–2018 and provides further insights on its interaction with other known particles.

tidyomics offers a software ecosystem for omic data manipulation and analysis that bridges Bioconductor with the tidyverse framework.

CAR-T targets are identified using logic gates and single-cell expression data.

Sekaly and colleagues reveal a common pre-vaccination peripheral blood transcriptional signature that is predictive of antibody responses across 13 different vaccines.

Donor-derived, EBV-specific CD8⁺ T cells engineered to express a high-affinity WT1-specific TCR established persistent T cell responses that safely prevented post-HCT relapse in patients with high-risk AML.