Bomback and Klemmer have systematically reviewed the literature on aldosterone breakthrough in people treated with angiotensin-converting-enzyme inhibitors and angiotensin-receptor blockers. Although the data are not yet supportive of widespread screening of asymptomatic patients, the authors contend that physicians should test for this phenomenon in selected patients and consider initiating treatment with aldosterone antagonists or renin inhibitors.
- Andrew S Bomback
- Philip J Klemmer
