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Despite it being almost 40 years since the discovery of the high-Tc superconducting cuprates, the underlying mechanisms governing their superconductivity are still not fully understood. Here, the authors use Green’s function strong-coupling lattice quantum Monte Carlo perturbation theory to investigate the spectral as well as superconducting properties of the doped t-t’ Hubbard model and consider the origin of the two-gap structure observed in the cuprates.

Anti-Russian sentiment and government sanctions have left many Russian scientists struggling to develop their careers abroad.

A proposed theoretical explanation for the electronic behaviour of moiré graphene is the coexistence of light and heavy electrons. Now local thermoelectric measurements hint that this model could be accurate.

Neutralising antibody levels are an important correlate of protection for pre-exposure prophylaxis against COVID-19, but it can be difficult to account for immune evasion of emerging virus variants. Here the authors present a variant-adjusted threshold of protection model, developed and validated with data from two clinical trials, which can be used to infer efficacy against any SARS-CoV-2 variant.

Photon Bose–Einstein condensation is observed in a semiconductor laser, where thermalization and condensation of photons occur using an InGaAs quantum well and an open microcavity. The distinction between regimes of photon Bose–Einstein condensation and conventional lasing are clearly identified.

The tumour-targeting activity and specificity of T cells with a CAR forming a reversible covalent bond with a hapten can be regulated by a small-molecule adapter that selectively binds to the hapten and to a chosen tumour antigen.

Genome-wide sequencing of 180 ancient individuals shows a continuous gradient of ancestry in Early-to-Mid-Holocene hunter-gatherers from the Baltic to the Transbaikal region and distinct contemporaneous groups in Northeast Siberia, and provides insights into the origins of modern Uralic and Yeniseian speakers.

The authors use systematic monitoring across the former USSR to investigate phenological changes across taxa. The long-term mean temperature of a site emerged as a strong predictor of phenological change, with further imprints of trophic level, event timing, site, year and biotic interactions.

Determining dynamics of Fe–CO bond breaking in heme proteins is essential to understand the interplay between protein function and dynamics. Here, the authors report the first experimental proof for the two-step CO photodissociation, involving the previously unknown slower ~15 ps process.

Exploiting the intrinsic response of magic-angle twisted bilayer graphene to resonant terahertz radiation, the interplay between electron interactions and quantum geometry is studied in such flat-band systems.

A versatile cloud-accessible single-photon-based quantum computing machine is developed, which shows a six-photon sampling rate of 4 Hz over weeks. Heralded generation of a three-photon Greenberger–Horne–Zeilinger state—a key milestone toward measurement-based quantum computing—is implemented.

Direct interaction between the small GTPase Rab7a and the cation channel TPC2 has been reported but the functional regulation is less clear. Here, the authors show that Rab7a enhances the activity of TPC2 to promote melanoma progression through the GSK3β/β-Catenin/MITF axis.

Bioethicists are setting up consultancies for research — but some scientists question whether they are needed.

Ovarian cancers frequently develop resistance to therapy. Here, using transcriptomics, proteomics, and preclinical models to analyse paired ascitic fluids before and after chemotherapy in ovarian cancer patients, the authors discover that extracellular secretion and spliceosomal components contribute to therapy resistance, enhancing the DNA damage response in recipient cancer cells.

Speleothem records from caves in Arctic Siberia allow for the reconstruction of multiannual air temperatures during the late Miocene (8.68±0.09 million years ago). These temperatures suggest that Eurasia was mostly permafrost-free during that time.

Observations indicating the chiral nature of superconducting states in five rhombohedral tetralayer and pentalayer graphene devices without moiré superlattice effects are reported, establishing a pure carbon material for the study of topological superconductivity.

Ahead of the third anniversary of Russia’s invasion of Ukraine, displaced academics describe their experiences settling into UK universities.

Neuroscientist Sergiy Sylantyev tells Nature that science and war cannot be separated.

Antibodies against SARS-CoV-2 S protein can provide a treatment strategy for COVID-19. Here, Guo et al. provide the crystal structure of a SARS-CoV2 neutralizing antibody isolated from a convalescent patient and highlight the therapeutic efficacy in a rhesus monkey model of an engineered version with optimized pharmacokinetic and safety profile.

Strategies to address the challenges associated with product manufacturing can improve chimeric antigen receptor (CAR) cell–based therapeutics. Here the authors report the results of two clinical trials in patients with B-cell malignancies, showing that place-of-care manufacturing has a low production failure rate with CD19-directed CAR-T cell products inducing high remission rates.

Venus' mesosphere is a transition region between the retrograde super rotation at the top of the thick clouds and the solar-antisolar circulation in the thermosphere. The mesospheric distributions of HF, HCl, H₂O and HDO are reported, and an unexpected extensive layer of warm air at altitudes 90–120 km on the nightside is found.

Spectroscopic measurements using nano-ARPES on twisted bilayer graphene directly highlight the presence of the flat bands.

Moiré potentials substantially alter the electronic properties of twisted bilayer graphene at a magic twist angle. A propagating plasmon mode, which can be observed with optical nano-imaging, is associated with transitions between the moiré minibands.

Observations of γ-rays with energies up to 1.4 PeV find that 12 sources in the Galaxy are PeVatrons, one of which is the Crab Nebula.

The integration of a TMDC monolayer into a high-Q microcavity enables the observation of optical valley Hall effect.

The ATLAS Collaboration reports the observation of the electroweak production of two jets and a Z-boson pair. This process is related to vector-boson scattering and allows the nature of electroweak symmetry breaking to be probed.

The ATLAS experiment at the Large Hadron Collider reports a search for charged-lepton-flavour violation in decays of Z bosons into a τ lepton and an electron or muon of opposite charge.

Non-equilibrium Bose–Einstein condensation of 7 ± 2 photons is observed in a sculpted dye-filled microcavity. The small number of particles allows the authors to access and characterize the non-equilibrium dynamics of the bosonic modes.

The ATLAS Collaboration reports a measurement of the ratio of the decay rates of W bosons to τ leptons and muons, in agreement with universal lepton couplings as postulated in the standard model of particle physics.