Nature Search

Excessive copper impairs intrahepatocyte trafficking and secretion of selenoprotein P

Selenium and copper are two essential trace elements whose homeostasis and distribution is regulated by hepatic release of selenoprotein P (SELENOP) and ceruloplasmin, respectively. Here, the authors show that excessive copper results in hepatic SELENOP accumulation in the trans Golgi which might limit the selenium transport to peripheral organs.

Maria Schwarz
Caroline E. Meyer
Anna P. Kipp
ResearchOpen Access13 Jun 2023
Nature Communications

Volume: 14, P: 1-15
Influenza vaccines promote humoral and cellular immune responses: a randomized, double-blind, phase 3 trial

The authors report a trial subset analysis of the immune responses induced by two inactivated quadrivalent influenza vaccines (QIVs): Sinovac QIV and Vaxigrip-Tetra™. Both vaccines elicit robust humoral responses and distinct T cell profiles.

Linmar Rodríguez-Guilarte
Constanza Méndez
Alexis M. Kalergis
ResearchOpen Access07 Dec 2025
Nature Communications

Volume: 17, P: 1-14
Rift linkage and inheritance determine collisional mountain belt evolution

Using 3D numerical models, this research shows how pre-existing rift basin structures influence the shape and growth of mountain belts, offering a way to link surface topography with deep Earth processes in regions like the Pyrenees and Caucasus.

Sebastian G. Wolf
Ritske S. Huismans
Dave A. May
ResearchOpen Access04 Dec 2025
Nature Communications

Volume: 17, P: 1-16
An MTF1 binding site disrupted by a homozygous variant in the promoter of ATP7B likely causes Wilson Disease

Heidi I. Chen
Karthik A. Jagadeesh
Gill Bejerano
Research07 Aug 2018
European Journal of Human Genetics

Volume: 26, P: 1810-1818
Predictive coding of reward in the hippocampus

Calcium imaging of mouse hippocampal neurons while mice learn a reward-based task over several weeks provides insight into the evolution of the hippocampal reward representation during extended periods of experience.

Mohammad Yaghoubi
M. Ganesh Kumar
Mark P. Brandon
Research14 Jan 2026
Nature

P: 1-7
Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1

Kenji Shimizu
Daniel Birnbaum
Michael Wigler
Research11 Aug 1983
Nature

Volume: 304, P: 497-500
Structural characterisation of the fungal Pmt4 homodimer

PMTs are fungal O-mannosyltransferases embedded in the ER membrane. Here, structures of the Pmt4 homodimer reveal distinct features of this PMT family and uncover an additional cytosolic binding site for the Dol-P-Man substrate lipid.

Melanie A. McDowell
Klemens Wild
Irmgard Sinning
ResearchOpen Access14 Dec 2025
Nature Communications

Volume: 16, P: 1-14
T_SCM-predominant allogeneic anti-BCMA CAR-T therapy for relapsed/refractory multiple myeloma: preclinical characterization and interim results from a phase 1 trial

CAR-T cell therapy has been shown to be effective in immunotherapy for treatment of several different tumours. Here the authors show pre-specified interim outcomes from a P-BCMA-ALLO1 trial with BCMA targeted CAR-T therapy in multiple myeloma.

Hubert Tseng
Bhagirathbhai Dholaria
Devon J. Shedlock
ResearchOpen Access24 Nov 2025
Nature Communications

Volume: 16, P: 1-14
A pan-cancer compendium of 1,294 plasma cell-free DNA methylomes and fragmentomes enabling multicancer detection

Zeng et al. analyzed cfDNA methylation and fragmentomic data from 1,294 patient plasma samples across 14 major cancer types to present a comprehensive landscape of pancancer and cancer-specific cell-free DNA methylation and fragmentomic features.

Yong Zeng
Dor D. Abelman
Housheng Hansen He
ResearchOpen Access19 Feb 2026
Nature Cancer

P: 1-15
A modular, multi-sensor crawler robot for adaptive pipeline inspection: design and experimental validation

Ahmed A. Abd Eltwab
Ahmed Sameh
ResearchOpen Access08 Jan 2026
Scientific Reports

Volume: 16, P: 1-26
Cross-ancestry comparison of aptamer and antibody protein measures

Affinity-proteomics platforms often yield poorly correlated measurements. Here, the authors show that protein-altering variants drive a portion of inter-platform inconsistency and that accounting for genetic variants can improve concordance of protein measures and phenotypic associations across ancestries.

Jayna C. Nicholas
Daniel H. Katz
Laura M. Raffield
ResearchOpen Access22 Jan 2026
Nature Communications

Volume: 17, P: 1-21
PTRAMP, CSS and Ripr form a conserved complex required for merozoite invasion of Plasmodium species into erythrocytes

The PCRCR complex of Plasmodium spp. binds basigin on the erythrocyte surface. While Rh5 of the complex is restricted to P. falciparum, PTRAMP, CSS and Ripr orthologs are present across the genus, for which the authors report common features.

Benjamin A. Seager
Pailene S. Lim
Stephen W. Scally
ResearchOpen Access26 Jan 2026
Nature Communications

Volume: 17, P: 1-17
Defining the clinical phenotype of Saul–Wilson syndrome

Carlos R. Ferreira
Wadih M. Zein
Michael B. Bober
Research17 Jan 2020
Genetics in Medicine

Volume: 22, P: 857-866
Strong and fragile topological Dirac semimetals with higher-order Fermi arcs

The existence of a topological bulk-boundary correspondence for Dirac semimetals has remained an open question. Here, Wieder et al. predict one-dimensional hinge states originating from bulk three-dimensional Dirac points in solid-state Dirac semimetals, revealing condensed matter Dirac fermions to be higher-order topological.

Benjamin J. Wieder
Zhijun Wang
B. Andrei Bernevig
ResearchOpen Access31 Jan 2020
Nature Communications

Volume: 11, P: 1-13
Immunogenicity and safety of co-purified diphtheria, tetanus and acellular pertussis vaccine in 6-year-old Chinese children

In this phase 4 trial, the authors compare the immunogenicity and safety of co-purified diphtheria, tetanus, and acellular pertussis combined vaccine (co-purified DTaP) to diphtheria and tetanus combined vaccine (DT) in 6-year-old Chinese children.

Xuewen Tang
Yanhui Xiao
Hanqing He
ResearchOpen Access29 Nov 2025
Nature Communications

Volume: 17, P: 1-10
Interstellar extinction in the Large Magellanic Cloud

K. Nandy
D. H. Morgan
L. Houziaux
Research21 Feb 1980
Nature

Volume: 283, P: 725-729
Comparative Immunochemical Properties of Nucleoproteins: Antigenic Characteristics of Deoxyribonucleic Acid Protein from a Canine Haemangiopericytoma

R. H. WILSON
V. JUREVICS
A. SCHRAM
Research12 Mar 1966
Nature

Volume: 209, P: 1102-1105
DIAGNOSIS OF WILSON DISEASE USING DNA MARKERS

R H J Houwen
G D Billingsley
D W Cox
Research01 May 1990
Pediatric Research

Volume: 27, P: 540
Trocar sleeve adapter accelerates silicone oil injection in real-world vitreoretinal surgery

Philip Wakili
Colya N. Englisch
Karl T. Boden
ResearchOpen Access06 Feb 2026
Eye

P: 1-6
IUE observations of absorption by hot gas in the nebula NGC6888

M. C. E. Huber
H. Nussbaumer
R. Wilson
Research19 Apr 1979
Nature

Volume: 278, P: 697-700
Global remodeling of ADP-ribosylation by PARP1 suppresses influenza A virus infection

Influenza A virus infection causes a dramatic upregulation of ADP-ribosylation that as part of the cellular antiviral response, a process that is counteracted by the viral NS1 protein.

Zhenyu Zhang
Isabel Uribe
Andrew Mehle
ResearchOpen Access17 Dec 2025
Nature Communications

Volume: 16, P: 1-17
Nucleophosmin supports WNT-driven hyperproliferation and tumor initiation

Npm1 promotes tumor formation via attenuating the integrated stress response and p53 activation in mouse WNT-driven intestinal and liver tumorigenesis.

Georgios Kanellos
Chiara Giacomelli
Owen J. Sansom
ResearchOpen Access18 Dec 2025
Nature Genetics

Volume: 58, P: 100-115
35 THE EVALUATION OF TREATMENT WITH ORAL ZINC FOR WILSON'S DISEASE

J Bouquet
M Sinaasappel
Z T Cossack
Research01 Sept 1988
Pediatric Research

Volume: 24, P: 411
Momentum Spectrum of Cosmic Rays at Sea-Level

F. ASHTON
G. BROOKE
A. W. WOLFENDALE
Research06 Feb 1960
Nature

Volume: 185, P: 364-365
Variation in Solar Insolation to the South Polar Region as a Trigger which Induces Instability in the Antarctic Ice Sheet

A. T. WILSON
Research30 Apr 1966
Nature

Volume: 210, P: 477-478
Evaluation of the Seasat wind scatterometer

W. L. Jones
D. H. Boggs
L. C. Schroeder
Research24 Dec 1981
Nature

Volume: 294, P: 704-707
Vulcanian eruption mechanisms

Stephen Self
Lionel Wilson
Ian A. Nairn
Research08 Feb 1979
Nature

Volume: 277, P: 440-443
Crystallographic studies on the activity of glycogen phosphorylase b

I. T. Weber
L. N. Johnson
J. A. Jenkins
Research03 Aug 1978
Nature

Volume: 274, P: 433-437
Dynamic pathways in energy landscapes guiding supramolecular Janus dendrimer self-assemblies between lamellar and cubic architectures

Energy landscapes encompassing both lamellar and inverse cubic assemblies remain rare in supramolecular systems. Here, authors achieve reversible vesicle–cubosome pathway selections via temperature-triggered non-covalent interactions using dynamic Janus dendrimers.

Jiabin Luan
Danni Wang
Daniela A. Wilson
ResearchOpen Access29 Aug 2025
Nature Communications

Volume: 16, P: 1-13
Successful ex vivo gene therapy directed to liver in a patient with familial hypercholesterolaemia

Mariann Grossman
Steven E. Raper
James M. Wilson
Research01 Apr 1994
Nature Genetics

Volume: 6, P: 335-341
Determination of the spin and parity of all-charm tetraquarks

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

A. Hayrapetyan
V. Makarenko
A. Snigirev
ResearchOpen Access03 Dec 2025
Nature

Volume: 648, P: 58-63
86 ⁶⁴COPPER-LOADING TEST AS INDICATOR OF ELEVATED LIVER-COPPER, E.G., IN WILSON'S DISEASE

C J A Van Den Hamer
T U Hoogenraad
Research01 Oct 1986
Pediatric Research

Volume: 20, P: 1048
Long-term unsupervised recalibration of cursor-based intracortical brain–computer interfaces using a hidden Markov model

A hidden Markov model that uses probabilistic retrospective inference allows for up to one month of unsupervised recalibration in an online cursor-based intracortical brain–machine interface.

Guy H. Wilson
Elias A. Stein
Francis R. Willett
ResearchOpen Access08 Dec 2025
Nature Biomedical Engineering

P: 1-19
Characterization of the most frequent ATP7B mutation causing Wilson disease in hepatocytes from patient induced pluripotent stem cells

Silvia Parisi
Elena V. Polishchuk
Stefano Bonatti
ResearchOpen Access19 Apr 2018
Scientific Reports

Volume: 8, P: 1-11
A unifying Bayesian framework for merging X-ray diffraction data

Observation of the chemical and conformational dynamics of biomolecules by diffraction methods is impeded by several physical artifacts. The authors present an extensible framework for accurate correction of such data that can keep pace with rapid developments in diffraction methods.

Kevin M. Dalton
Jack B. Greisman
Doeke R. Hekstra
ResearchOpen Access15 Dec 2022
Nature Communications

Volume: 13, P: 1-13
An interstellar energetic and non-aqueous pathway to peptide formation

The formation of glycylglycine, a simple peptide molecule, is possible under non-aqueous interstellar conditions, according to laboratory experiments. Thus, complex organics with biological relevance may predate planetary accretion.

Alfred Thomas Hopkinson
Ann Mary Wilson
Sergio Ioppolo
Research20 Jan 2026
Nature Astronomy

P: 1-9
Ligase-mediated programmable genomic integration (L-PGI)

Therapeutic gene editing in vivo is an ongoing challenge. Here, authors demonstrate Cas9 nickase guided DNA ligation as a nonviral method for installing permanent genomic corrections with favorable on target edit profiles in model animal cell types and adult mice.

Angela X. Nan
Michael Chickering
Jenny Xie
ResearchOpen Access10 Dec 2025
Nature Communications

Volume: 17, P: 1-13
Microbial collagenase activity is linked to oral–gut translocation in advanced chronic liver disease

While oral bacteria rarely colonize the healthy gut, they dominate the gut microbiome of patients with chronic liver disease. Here a bacterial gene encoded by microbial translocators is linked to gut barrier disruption and fibrosis.

Shen Jin
Aurelie Cenier
Melanie Schirmer
ResearchOpen Access29 Dec 2025
Nature Microbiology

Volume: 11, P: 211-227
Surface of the Ocean as a Source of Air-Borne Nitrogenous Material and other Plant Nutrients

A. T. WILSON
Research11 Jul 1959
Nature

Volume: 184, P: 99-101
Expression of a microinjected immunoglobulin gene in the spleen of transgenic mice

Ralph L. Brinster
Kindred A. Ritchie
Ursula Storb
Research24 Nov 1983
Nature

Volume: 306, P: 332-336
Hepatic zonation determines tumorigenic potential of mutant β-catenin

Zonal positioning in the liver determines whether the CTNNB1 oncogene can induce liver cancer.

Alexander Raven
Kathryn Gilroy
Owen J. Sansom
ResearchOpen Access19 Nov 2025
Nature

Volume: 649, P: 739-748
Crystallographic observation of a trapped tetrahedral intermediate in a metalloenzyme

David K. Wilson
Florante A. Quiocho
Research01 Oct 1994
Nature Structural Biology

Volume: 1, P: 691-694
Analytical investigation of soliton propagation in conformable fractional-order transmission line metamaterials

Ehab M. Almetwally
Mohammad A. Zayed
Ahmed S. Rashed
ResearchOpen Access12 Feb 2026
Scientific Reports

Volume: 16, P: 1-15
Lake Bonney, Taylor Valley, Antarctica: a Natural Solar Energy Trap

R. A. HOARE
K. B. POPPLEWELL
A. T. WILSON
Research30 May 1964
Nature

Volume: 202, P: 886-888
Formation of discrete islands in linear island chains

John N. Skilbeck
John A. Whitehead Jr
Research06 Apr 1978
Nature

Volume: 272, P: 499-501
Mutational analysis of ATP7B gene in Egyptian children with Wilson disease: 12 novel mutations

Tawhida Y. Abdelghaffar
Solaf M. Elsayed
Hartmut Schmidt
Research01 Aug 2008
Journal of Human Genetics

Volume: 53, P: 681-687
Modelling dysfunction-specific interventions for seizure termination in epilepsy

Aravind Kumar Kamaraj
Matthew Parker Szuromi
ResearchOpen Access19 Dec 2025
npj Systems Biology and Applications

Volume: 12, P: 1-13
Ultra-high-throughput mapping of genetic design space

CLASSIC is a high-throughput genetic profiling platform that combines long- and short-read next-generation-sequencing modalities to quantitatively assess pools of constructs of arbitrary length containing diverse genetic part compositions.

Kshitij Rai
Ronan W. O’Connell
Caleb J. Bashor
Research14 Jan 2026
Nature

Volume: 650, P: 1035-1044
Molecular Structure of α-Keratin

R. D. B. FRASER
T. P. MacRAE
A. MILLER
Research01 Sept 1964
Nature

Volume: 203, P: 1231-1233
Sensitive measurement of fluctuations in the cosmic microwave background

R. D. Davies
A. N. Lasenby
R. Rebolo
Research01 Apr 1987
Nature

Volume: 326, P: 462-465

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