Nature Search

Smaller total and subregional cerebellar volumes in posttraumatic stress disorder: a mega-analysis by the ENIGMA-PGC PTSD workgroup

Ashley A. Huggins
C. Lexi Baird
Rajendra Morey
ResearchOpen Access10 Jan 2024
Molecular Psychiatry

Volume: 29, P: 611-623
Hemoglobin Cheverly: an Unstable Hemoglobin Associated with Chronic Mild Anemia

Andrew M Yeager
William H Zinkham
Winston F Moo-Penn
Research01 Jun 1983
Pediatric Research

Volume: 17, P: 503-507
Multi-ancestry genome-wide association study of kidney cancer identifies 63 susceptibility regions

A multi-ancestry genome-wide association meta-analysis of kidney cancer identifies 63 regions associated with disease susceptibility including one locus that was associated with increased risk in individuals with African ancestry.

Mark P. Purdue
Diptavo Dutta
Stephen J. Chanock
Research26 Apr 2024
Nature Genetics

Volume: 56, P: 809-818
Author Correction: Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer

Kadir C. Akdemir
Victoria T. Le
Christian von Mering
Amendments and CorrectionsOpen Access21 Mar 2023
Nature Genetics

Volume: 55, P: 1079
Author Correction: Genomic footprints of activated telomere maintenance mechanisms in cancer

Lina Sieverling
Chen Hong
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
Author Correction: Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition

Bernardo Rodriguez-Martin
Eva G. Alvarez
Christian von Mering
Amendments and CorrectionsOpen Access21 Mar 2023
Nature Genetics

Volume: 55, P: 1080
Author Correction: High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations

Yiqun Zhang
Fengju Chen
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
Author Correction: Analyses of non-coding somatic drivers in 2,658 cancer whole genomes

Esther Rheinbay
Morten Muhlig Nielsen
Christian von Mering
Amendments and CorrectionsOpen Access25 Jan 2023
Nature

Volume: 614, P: E40
Author Correction: Patterns of somatic structural variation in human cancer genomes

Yilong Li
Nicola D. Roberts
Christian von Mering
Amendments and CorrectionsOpen Access25 Jan 2023
Nature

Volume: 614, P: E38
Author Correction: A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns

Wei Jiao
Gurnit Atwal
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
Author Correction: Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

Isidro Cortés-Ciriano
Jake June-Koo Lee
Christian von Mering
Amendments and CorrectionsOpen Access21 Mar 2023
Nature Genetics

Volume: 55, P: 1076
Rare coding variants in ten genes confer substantial risk for schizophrenia

Whole-exome sequencing identifies ten risk genes for schizophrenia implicated by rare protein-coding variants, a subset of which overlap with risk genes in other neurodevelopmental disorders.

Tarjinder Singh
Timothy Poterba
Mark J. Daly
Research08 Apr 2022
Nature

Volume: 604, P: 509-516
Central Executive Network drives delta-9-tetrahydrocannabinol (THC)-induced nonlinear changes in large-scale functional connectivity in adolescent nonhuman primates

Andrew Jin Soo Byun
Harshawardhan U. Deshpande
Stephen J. Kohut
Research28 Feb 2025
Neuropsychopharmacology

Volume: 50, P: 1743-1751
Long-term cellular immunity of vaccines for Zaire Ebola Virus Diseases

In this immunological ancillary study of the PREVAC trial, the authors show that approved Ebola virus vaccines induce memory T-cell responses that persist during the five year follow-up after initial vaccination.

Aurélie Wiedemann
Edouard Lhomme
Huanying Zhou
ResearchOpen Access03 Sept 2024
Nature Communications

Volume: 15, P: 1-15
Borderline personality disorder

Borderline personality disorder is characterized by sensitivity to perceived interpersonal slights, an unstable sense of self, intense emotions and impulsive behaviours. This Primer by Gunderson et al. discusses the epidemiology, mechanisms, diagnosis and management of borderline personality disorder.

John G. Gunderson
Sabine C. Herpertz
Mary C. Zanarini
Reviews24 May 2018
Nature Reviews Disease Primers

Volume: 4, P: 1-20
DeepNull models non-linear covariate effects to improve phenotypic prediction and association power

GWAS often assume a linear phenotype-covariate relationship which may not hold in practice. Here the authors present DeepNull, in which they apply deep learning to identify and adjust for complex non-linear relationships, improving phenotypic prediction and GWAS power.

Zachary R. McCaw
Thomas Colthurst
Farhad Hormozdiari
ResearchOpen Access11 Jan 2022
Nature Communications

Volume: 13, P: 1-10
Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism

Mannan, a component of yeast cell walls, is shown to be a viable food source for Bacteroides thetaiotamicron, a dominant member of the gut microbiota, which catabolizes the mannan ‘selfishly’—countering the general assumption that multiple members of the gut microbiota take a role in, and benefit from, polysaccharide catabolism.

Fiona Cuskin
Elisabeth C. Lowe
Harry J. Gilbert
Research07 Jan 2015
Nature

Volume: 517, P: 165-169
Inference of chronic obstructive pulmonary disease with deep learning on raw spirograms identifies new genetic loci and improves risk models

A deep convolutional neural network calculates liability scores for chronic obstructive pulmonary disease (COPD) from raw spirogram traces and noisy medical-record-based labels in the UK Biobank. Genome-wide analyses using these scores replicate known loci for lung function and identify 67 new disease loci.

Justin Cosentino
Babak Behsaz
Farhad Hormozdiari
Research17 Apr 2023
Nature Genetics

Volume: 55, P: 787-795
Author Correction: Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

Matthew H. Bailey
William U. Meyerson
Christian von Mering
Amendments and CorrectionsOpen Access30 Nov 2020
Nature Communications

Volume: 11, P: 1
Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics

Phenotypic variation and diseases are influenced by factors such as genetic variants and gene expression. Here, Barbeira et al. develop S-PrediXcan to compute PrediXcan results using summary data, and investigate the effects of gene expression variation on human phenotypes in 44 GTEx tissues and >100 phenotypes.

Alvaro N. Barbeira
Scott P. Dickinson
Hae Kyung Im
ResearchOpen Access08 May 2018
Nature Communications

Volume: 9, P: 1-20
Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects

The CNV analysis group of the Psychiatric Genomic Consortium analyzes a large schizophrenia cohort to examine genomic copy number variants (CNVs) and disease risk. They find an enrichment of CNV burden in cases versus controls and identify 8 genome-wide significant loci as well as novel suggestive loci conferring either risk or protection to schizophrenia.

Christian R Marshall
Daniel P Howrigan
Jonathan Sebat
Research21 Nov 2016
Nature Genetics

Volume: 49, P: 27-35
Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer

Roger Milne and colleagues conduct a genome-wide association study for estrogen receptor (ER)-negative breast cancer combined with BRCA1 mutation carriers in a large cohort. They identify ten new risk variants and find high genetic correlation between breast cancer risk for BRCA1 mutation carriers and risk of ER-negative breast cancer in the general population.

Roger L Milne
Karoline B Kuchenbaecker
Jacques Simard
Research23 Oct 2017
Nature Genetics

Volume: 49, P: 1767-1778
Author Correction: Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig

Yulia Rubanova
Ruian Shi
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
Author Correction: Combined burden and functional impact tests for cancer driver discovery using DriverPower

Shimin Shuai
Federico Abascal
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
Author Correction: Divergent mutational processes distinguish hypoxic and normoxic tumours

Vinayak Bhandari
Constance H. Li
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
Author Correction: Pathway and network analysis of more than 2500 whole cancer genomes

Matthew A. Reyna
David Haan
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
A global horizon scan of the future impacts of robotics and autonomous systems on urban ecosystems

The future challenges and potential opportunities of robotics and autonomous systems in urban ecosystems, and how they may impact biodiversity, are explored and prioritized via a global horizon scan of 170 experts.

Mark A. Goddard
Zoe G. Davies
Martin Dallimer
Research04 Jan 2021
Nature Ecology & Evolution

Volume: 5, P: 219-230
Author Correction: Pan-cancer analysis of whole genomes

Lauri A. Aaltonen
Federico Abascal
Christian von Mering
Amendments and CorrectionsOpen Access25 Jan 2023
Nature

Volume: 614, P: E39
Author Correction: The landscape of viral associations in human cancers

Marc Zapatka
Ivan Borozan
Christian von Mering
Amendments and CorrectionsOpen Access21 Mar 2023
Nature Genetics

Volume: 55, P: 1077
Author Correction: The repertoire of mutational signatures in human cancer

Ludmil B. Alexandrov
Jaegil Kim
Christian von Mering
Amendments and CorrectionsOpen Access25 Jan 2023
Nature

Volume: 614, P: E41
Author Correction: Genomic basis for RNA alterations in cancer

Claudia Calabrese
Natalie R. Davidson
Christian von Mering
Amendments and CorrectionsOpen Access25 Jan 2023
Nature

Volume: 614, P: E37
Author Correction: Integrative pathway enrichment analysis of multivariate omics data

Marta Paczkowska
Jonathan Barenboim
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
Author Correction: Comprehensive molecular characterization of mitochondrial genomes in human cancers

Yuan Yuan
Young Seok Ju
Christian von Mering
Amendments and CorrectionsOpen Access21 Mar 2023
Nature Genetics

Volume: 55, P: 1078
Author Correction: Inferring structural variant cancer cell fraction

Marek Cmero
Ke Yuan
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
Author Correction: The evolutionary history of 2,658 cancers

Moritz Gerstung
Clemency Jolly
Christian von Mering
Amendments and CorrectionsOpen Access25 Jan 2023
Nature

Volume: 614, P: E42
Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

Benedict D. Michael
Cordelia Dunai
David K. Menon
Amendments and CorrectionsOpen Access04 Apr 2024
Nature Communications

Volume: 15, P: 1
A randomized proof-of-mechanism trial applying the ‘fast-fail’ approach to evaluating κ-opioid antagonism as a treatment for anhedonia

A phase 2 proof-of-mechanism trial shows that a κ-opioid receptor antagonist improves reward-related functioning in the brain and a clinical measure of anhedonia in patients with mood and anxiety disorders, serving as a model for implementing the ‘fast-fail’ approach to psychiatric treatment development.

Andrew D. Krystal
Diego A. Pizzagalli
William Z. Potter
Research30 Mar 2020
Nature Medicine

Volume: 26, P: 760-768
Linking microbial Sphagnum degradation and acetate mineralization in acidic peat bogs: from global insights to a genome-centric case study

Andrew R. St. James
Joseph B. Yavitt
Ruth E. Richardson
Research19 Sept 2020
The ISME Journal

Volume: 15, P: 293-303
Dynamic landscape and regulation of RNA editing in mammals

Using the GTEx data and others, a comprehensive analysis of adenosine-to-inosine RNA editing in mammals is presented; targets of the various ADAR enzymes are identified, as are several potential regulators of editing, such as AIMP2.

Meng How Tan
Qin Li
Jin Billy Li
Research12 Oct 2017
Nature

Volume: 550, P: 249-254
Landscape of X chromosome inactivation across human tissues

Multiple transcriptome approaches, including single-cell sequencing, demonstrate that escape from X chromosome inactivation is widespread and occasionally variable between cells, chromosomes, and tissues, resulting in sex-biased expression of at least 60 genes and potentially contributing to sex-specific differences in health and disease.

Taru Tukiainen
Alexandra-Chloé Villani
Daniel G. MacArthur
ResearchOpen Access12 Oct 2017
Nature

Volume: 550, P: 244-248
The impact of rare variation on gene expression across tissues

The authors show that rare genetic variants contribute to large gene expression changes across diverse human tissues and provide an integrative method for interpretation of rare variants in individual genomes.

Xin Li
Yungil Kim
Stephen B. Montgomery
ResearchOpen Access12 Oct 2017
Nature

Volume: 550, P: 239-243
Correction: Corrigendum: Whole-genome landscape of pancreatic neuroendocrine tumours

Aldo Scarpa
David K. Chang
Sean M. Grimmond
Amendments and Corrections27 Sept 2017
Nature

Volume: 550, P: 548
Plzf is required in adult male germ cells for stem cell self-renewal

F William Buaas
Andrew L Kirsh
Robert E Braun
Research23 May 2004
Nature Genetics

Volume: 36, P: 647-652
Mutations in the gene encoding peroxisomal α-methylacyl-CoA racemase cause adult-onset sensory motor neuropathy

Sacha Ferdinandusse
Simone Denis
Ronald J.A. Wanders
Research01 Feb 2000
Nature Genetics

Volume: 24, P: 188-191
The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression

Andrew S. Turnell
Grant S. Stewart
Phillip H. Gallimore
Research01 Dec 2005
Nature

Volume: 438, P: 690-695
A genome-wide linkage and association scan reveals novel loci for autism

Autism is a highly heritable neurodevelopmental disorder, and yet few specific susceptibility genes have been identified to date. A linkage and association mapping study using half a million genome-wide single nucleotide polymorphisms is now described in a common set of 1,031 multiplex autism families. The linkage regions identified provide targets for rare variation screening whereas the discovery of a single novel association, SEMA5A, demonstrates the action of common variants.

Lauren A. Weiss
Dan E. Arking
Leena Peltonen
Research08 Oct 2009
Nature

Volume: 461, P: 802-808
Whole-genome sequencing of bladder cancers reveals somatic CDKN1A mutations and clinicopathological associations with mutation burden

Bladder cancer is a complex genetic disease and a common cause of death due to malignancy. Here, the authors carry out whole-genome sequencing of 14 bladder cancers to characterize the genomic landscape of the disease and show that mutational burden is associated with tumour progression in these samples.

J. -B. Cazier
S. R. Rao
F. C. Hamdy
ResearchOpen Access29 Apr 2014
Nature Communications

Volume: 5, P: 1-13
Author Correction: Hyperpolarised ¹³C-MRI identifies the emergence of a glycolytic cell population within intermediate-risk human prostate cancer

Nikita Sushentsev
Mary A. McLean
Ferdia A. Gallagher
Amendments and CorrectionsOpen Access07 Mar 2022
Nature Communications

Volume: 13, P: 1
Polyketide and nonribosomal peptide retro-biosynthesis and global gene cluster matching

Two programs, GRAPE and GARLIC, work together to first predict biosynthetic gene clusters responsible for the production of polyketides and nonribosomal peptides, then link sequenced gene clusters to known and unknown natural products.

Chris A Dejong
Gregory M Chen
Nathan A Magarvey
Research03 Oct 2016
Nature Chemical Biology

Volume: 12, P: 1007-1014
The evolution of parental care diversity in amphibians

Parental care can take many forms but how this diversity arises is not well understood. Here, the authors compile data for over 1300 amphibian species and show that different forms of care evolve at different rates, prolonged care can be easily reduced, and biparental care is evolutionarily unstable.

Andrew I. Furness
Isabella Capellini
ResearchOpen Access17 Oct 2019
Nature Communications

Volume: 10, P: 1-12

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