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Differential Activation by Restraint Stress of a Mechanism to conserve Brain Catecholamines and Serotonin in Mice differing in Excitability

BRUCE L. WELCH
ANNEMARIE S. WELCH
Research01 May 1968
Nature

Volume: 218, P: 575-577
Intermolecular biparatopic trapping of ErbB2 prevents compensatory activation of PI3K/AKT via RAS–p110 crosstalk

Targeted therapy of ErbB2-dependent tumours often provokes an adaptive response leading to reactivation of the PI3K/AKT pathway. Here the authors identify an ErbB3-independent compensatory mechanism comprising Ras/PI3K activation directly by ErbB2, and develop biparatopic panErbB inhibitors to block this mode of resistance.

Rastislav Tamaskovic
Martin Schwill
Andreas Plückthun
ResearchOpen Access03 Jun 2016
Nature Communications

Volume: 7, P: 1-18
Normothermic human kidney preservation drives iron accumulation and ferroptosis

Ex vivo normothermic machine perfusion has been proposed to protect donor kidneys. Here, the authors show that red blood cell-based human kidney perfusion and associated hemolysis contribute to iron accumulation, ferroptosis, and kidney injury.

Marlon J. A. de Haan
Marleen E. Jacobs
Ton J. Rabelink
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-13
Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control

Viral gene therapy can be limited by the efficacy of virion sequestration, immune responses and the silencing of genetic payloads. Here the authors engineer an advenovirus protein coat which shields the virion from the immune system while targeting cancer cells.

Markus Schmid
Patrick Ernst
Andreas Plückthun
ResearchOpen Access31 Jan 2018
Nature Communications

Volume: 9, P: 1-16
Engineering an anti-HER2 biparatopic antibody with a multimodal mechanism of action

HER2 acts an oncogenic driver in numerous cancers. Here, the authors design an anti-HER2 biparatopic and tetravalent IgG fusion with inhibitory effects in a xenograft model.

Florian Kast
Martin Schwill
Andreas Plückthun
ResearchOpen Access18 Jun 2021
Nature Communications

Volume: 12, P: 1-18
FUS-mediated regulation of acetylcholine receptor transcription at neuromuscular junctions is compromised in amyotrophic lateral sclerosis

The authors report that the ALS-associated gene FUS stimulates transcription of acetylcholine receptor subunit genes in subsynaptic myonuclei. ALS mutations distort this mechanism, inducing muscle-intrinsic toxicity that may contribute to dying-back motor neuronopathy.

Gina Picchiarelli
Maria Demestre
Erik Storkebaum
Research07 Oct 2019
Nature Neuroscience

Volume: 22, P: 1793-1805
Deletion of a DNA sequence at the chromosomal region 3p21 in all major types of lung cancer

Klaas Kok
Jan Osinga
Charles H. C. M. Buys
Research10 Dec 1987
Nature

Volume: 330, P: 578-581
Prolonged normothermic perfusion of the kidney prior to transplantation: a historically controlled, phase 1 cohort study

Kidney transplantation usually relies on hypothermia to safely preserve the graft. Here, the authors show that keeping kidneys at 37°C, using a machine to supply them with blood, oxygen, and nutrition, is feasible for up to 24 hours, and may be useful for testing and treating them pre-transplant.

Richard Dumbill
Simon Knight
Peter Friend
ResearchOpen Access17 May 2025
Nature Communications

Volume: 16, P: 1-15
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

Felicity Liew
Claudia Efstathiou
J. Eunice Zhang
ResearchOpen Access08 Apr 2024
Nature Immunology

Volume: 25, P: 607-621
Local immune cell contributions to fracture healing in aged individuals – A novel role for interleukin 22

Christian H. Bucher
Julia C. Berkmann
Katharina Schmidt-Bleek
ResearchOpen Access26 Aug 2022
Experimental & Molecular Medicine

Volume: 54, P: 1262-1276
Neonatal immune cells have heightened responses following in-utero exposure to chorioamnionitis or COVID-19

Annemarie Gilley
Timothy J. Boly
Jennifer Bermick
Research10 Nov 2023
Pediatric Research

Volume: 95, P: 1483-1492
Neuropathy-associated Tecpr2 mutation knock-in mice reveal endolysosomal loss of function phenotypes in neurons and microglia

Debjani Bhattacharya
Patricia da Silva-Buttkus
Christian Behrends
ResearchOpen Access31 Oct 2025
Cell Death & Disease

Volume: 16, P: 1-19
Long-read sequence and assembly of segmental duplications

Segmental Duplication Assembler (SDA) uses long sequence reads to resolve segmental duplications that are collapsed in current genome assemblies. These assemblies correspond in total to the length of an average human chromosome.

Mitchell R. Vollger
Philip C. Dishuck
Evan E. Eichler
Research17 Dec 2018
Nature Methods

Volume: 16, P: 88-94
Evidence for opposing selective forces operating on human-specific duplicated TCAF genes in Neanderthals and humans

Duplications of gene segments can allow novel physiological adaptations to evolve. A detailed analysis of the TCAF gene family in primates and archaic humans suggest rapid duplication and diversification in this gene family is associated with cold or dietary adaptations.

PingHsun Hsieh
Vy Dang
Evan E. Eichler
ResearchOpen Access25 Aug 2021
Nature Communications

Volume: 12, P: 1-14
Multi-platform discovery of haplotype-resolved structural variation in human genomes

Structural variants (SVs) in human genomes contribute diversity and diseases. Here, the authors use a multi-platform strategy to generate haplotype-resolved SVs for three human parent–child trios.

Mark J. P. Chaisson
Ashley D. Sanders
Charles Lee
ResearchOpen Access16 Apr 2019
Nature Communications

Volume: 10, P: 1-16
Septins are critical regulators of osteoclastic bone resorption

Anaïs M. J. Møller
Ernst-Martin Füchtbauer
Kent Søe
ResearchOpen Access29 Aug 2018
Scientific Reports

Volume: 8, P: 1-15
Aspergillus fumigatus establishes infection in zebrafish by germination of phagocytized conidia, while Aspergillus niger relies on extracellular germination

Bjørn E. V. Koch
Natalia H. Hajdamowicz
Annemarie H. Meijer
ResearchOpen Access05 Sept 2019
Scientific Reports

Volume: 9, P: 1-13
Comparison of UK paediatric SARS-CoV-2 admissions across the first and second pandemic waves

Olivia V. Swann
Louisa Pollock
Malcolm G. Semple
ResearchOpen Access22 Apr 2022
Pediatric Research

Volume: 93, P: 207-216

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Differential Activation by Restraint Stress of a Mechanism to conserve Brain Catecholamines and Serotonin in Mice differing in Excitability

Intermolecular biparatopic trapping of ErbB2 prevents compensatory activation of PI3K/AKT via RAS–p110 crosstalk

Normothermic human kidney preservation drives iron accumulation and ferroptosis

Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control

Engineering an anti-HER2 biparatopic antibody with a multimodal mechanism of action

FUS-mediated regulation of acetylcholine receptor transcription at neuromuscular junctions is compromised in amyotrophic lateral sclerosis

Deletion of a DNA sequence at the chromosomal region 3p21 in all major types of lung cancer

Prolonged normothermic perfusion of the kidney prior to transplantation: a historically controlled, phase 1 cohort study

Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Local immune cell contributions to fracture healing in aged individuals – A novel role for interleukin 22

Neonatal immune cells have heightened responses following in-utero exposure to chorioamnionitis or COVID-19

Neuropathy-associated Tecpr2 mutation knock-in mice reveal endolysosomal loss of function phenotypes in neurons and microglia

Long-read sequence and assembly of segmental duplications

Evidence for opposing selective forces operating on human-specific duplicated TCAF genes in Neanderthals and humans

Multi-platform discovery of haplotype-resolved structural variation in human genomes

Septins are critical regulators of osteoclastic bone resorption

Aspergillus fumigatus establishes infection in zebrafish by germination of phagocytized conidia, while Aspergillus niger relies on extracellular germination

Comparison of UK paediatric SARS-CoV-2 admissions across the first and second pandemic waves

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