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Showing 1–4 of 4 results
Advanced filters: Author: Aaron A. Smargon Clear advanced filters

  • Smargon et al. show that small nuclear RNAs can improve the cellular safety and efficacy of endogenous protein-mediated RNA base editing, enhancing nuclear RNA editing and the rescue of premature termination codon disease.

    • Aaron A. Smargon
    • Deepak Pant
    • Gene W. Yeo
    ResearchOpen Access
    Nature Chemical Biology
    P: 1-9

  • The off-target effects of CRISPR-Cas9 are thought to be mediated by its cognate guide RNA. Here the authors show that Cas9 independently interacts with the human transcriptome, correlating with elevated RNA editing even under guide RNA co-expression.

    • Aaron A. Smargon
    • Assael A. Madrigal
    • Gene W. Yeo
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-8

  • Class 2 CRISPR–Cas systems are characterized by effector modules that consist of a single multidomain protein. In this Analysis, using a computational pipeline, the authors discover three novel families of class 2 effectors that correspond to three new CRISPR–Cas subtypes and present a comprehensive census of class 2 systems that are encoded in complete and draft bacterial and archaeal genomes.

    • Sergey Shmakov
    • Aaron Smargon
    • Eugene V. Koonin
    Research
    Nature Reviews Microbiology
    Volume: 15, P: 169-182