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Nature Immunology (3)
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Showing 1–5 of 5 results

Advanced filters: Author: Aaron Arvey Clear advanced filters

GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses

Michael K. Lo
Robert Jordan
Christina F. Spiropoulou
ResearchOpen Access06 Mar 2017
Scientific Reports

Volume: 7, P: 1-7
Inflammation-induced repression of chromatin bound by the transcription factor Foxp3 in regulatory T cells

The transcription factor Foxp3 is essential for the function of regulatory T cells (T_reg cells). Rudensky and colleagues show binding of Foxp3 poises target genes for repression and, after activation of T_reg cells, recruits the histone methyltransferase Ezh2.

Aaron Arvey
Joris van der Veeken
Alexander Y Rudensky
Research13 Apr 2014
Nature Immunology

Volume: 15, P: 580-587
Continuous requirement for the TCR in regulatory T cell function

Regulatory T cells help to keep adaptive immunity in check. Rudensky and colleagues show that these cells continuously require TCR signaling to maintain their cellular identity and homeostasis and to exert their suppressive ability.

Andrew G Levine
Aaron Arvey
Alexander Y Rudensky
Research28 Sept 2014
Nature Immunology

Volume: 15, P: 1070-1078
Transcription factor Foxp3 and its protein partners form a complex regulatory network

The transcription factor Foxp3 is essential for the function of regulatory T cells. Rudensky and colleagues show Foxp3 participates in large protein complexes that regulate gene expression of many of these components in self-reinforcing networks.

Dipayan Rudra
Paul deRoos
Alexander Y Rudensky
Research26 Aug 2012
Nature Immunology

Volume: 13, P: 1010-1019
Evaluation of methods for modeling transcription factor sequence specificity

The most comprehensive analysis to date of models of transcription-factor binding specificity reveals the best methods for predicting in vivo binding from in vitro data.

Matthew T Weirauch
Atina Cote
Timothy R Hughes
Research27 Jan 2013
Nature Biotechnology

Volume: 31, P: 126-134