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Advanced filters: Author: Aaron C. Bini Clear advanced filters

Binimetinib and encorafenib for the treatment of advanced solid tumors with non-V600E BRAF mutations: results from the Phase II BEAVER trial

There is a lack of effective therapies for patients with non-V600E BRAF mutant cancer. Here, the authors report limited response in a phase II trial investigating the combination of binimetinib (MEK inhibitor) and encorafenib (BRAF inhibitor) for the treatment of non-V600E BRAF mutant cancer and subsequently investigate resistance mechanisms and combination therapeutic strategies in patient-derived models.

April A. N. Rose
Jennifer Maxwell
Anna Spreafico
ResearchOpen Access03 Jan 2026
Nature Communications

Volume: 17, P: 1-19
Proximity of mRNA5′-region and 18S rRNA in eukaryotic initiation complexes

Kunio Nakashima
Edward Darzynkiewicz
Aaron J. Shatkin
Research17 Jul 1980
Nature

Volume: 286, P: 226-230
Rapid early Holocene retreat of a Laurentide outlet glacier through an Arctic fjord

Marine-terminating outlet glaciers control the stability of ice sheets. Exposure ages and radiocarbon dates show that an Arctic outlet glacier of the Laurentide ice sheet rapidly retreated about 9,500 years ago, and imply strong feedbacks between bathymetry and ice movement.

Jason P. Briner
Aaron C. Bini
Robert S. Anderson
Research21 Jun 2009
Nature Geoscience

Volume: 2, P: 496-499

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