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Showing 1–12 of 12 results
Advanced filters: Author: Aaron Döring Clear advanced filters

  • Lipid concentration in the serum is one of the most important risk factors for coronary artery disease and can be targeted for therapeutic intervention. A genome-wide association study in >100,000 individuals of European ancestry now finds 95 significantly associated loci that also affect lipid traits in non-European populations. Among associated loci are those involved in cholesterol metabolism, known targets of cholesterol-lowering drugs and those that contribute to normal variation in lipid traits and to extreme lipid phenotypes.

    • Tanya M. Teslovich
    • Kiran Musunuru
    • Sekar Kathiresan
    Research
    Nature
    Volume: 466, P: 707-713

  • Anna Köttgen and colleagues report genome-wide association studies for serum urate in over 140,000 individuals from the Global Urate Genetics Consortium (GUGC). They identify 18 loci newly associated with serum urate concentrations and confirm 10 known loci, characterize their associations with gout and include a network analysis suggesting a role for inhibins-activins pathways in regulating urate homeostasis.

    • Anna Köttgen
    • Eva Albrecht
    • Christian Gieger
    Research
    Nature Genetics
    Volume: 45, P: 145-154

  • Past genome-wide associate studies have identified hundreds of genetic loci that influence body size and shape when examined one trait at a time. Here, Jeff and colleagues develop an aggregate score of various body traits, and use meta-analysis to find new loci linked to body shape.

    • Janina S. Ried
    • Janina Jeff M.
    • Ruth J. F. Loos
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-11

  • A meta-analysis of genome-wide association studies in more than 66,000 individuals identifies 68 new genomic loci that reliably associate with platelet count and volume, and reveals new gene functions.

    • Christian Gieger
    • Aparna Radhakrishnan
    • Nicole Soranzo
    Research
    Nature
    Volume: 480, P: 201-208

  • Cristen Willer and colleagues report genome-wide association analyses for blood lipid levels in 188,578 individuals. They identify 62 loci newly associated with blood lipid levels, refine the association signals at 12 loci and examine associations with cardiovascular and metabolic traits.

    • Cristen J Willer
    • Ellen M Schmidt
    • Gonçalo R Abecasis
    Research
    Nature Genetics
    Volume: 45, P: 1274-1283

  • Leena Peltonen and colleagues report a genome-wide association study of cholesterol and triglyceride levels in 16 population-based cohorts across Europe. Six new loci were identified, and overall a genetic risk score improves the screening of high risk groups for dyslipidemia.

    • Yurii S Aulchenko
    • Samuli Ripatti
    • Leena Peltonen
    Research
    Nature Genetics
    Volume: 41, P: 47-55

  • This review focuses on chiral carbon dots, introducing their chemical syntheses, morphology and optical/chiroptical properties, and considering their emerging applications in sensing, bioimaging and catalysis.

    • Aaron Döring
    • Elena Ushakova
    • Andrey L. Rogach
    ReviewsOpen Access
    Light: Science & Applications
    Volume: 11, P: 1-23