Nature Search

Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes

Fine-mapping of causal variants and integration of epigenetic and chromatin conformation data identify likely target genes for 150 breast cancer risk regions.

Laura Fachal
Hugues Aschard
Alison M. Dunning
Research07 Jan 2020
Nature Genetics

Volume: 52, P: 56-73
A distinct cortical code for socially learned threat

Studies in mice show that observational fear learning is encoded by neurons in the dorsomedial prefrontal cortex in a manner that is distinct from the encoding of fear learned by direct experience.

Shana E. Silverstein
Ruairi O’Sullivan
Andrew Holmes
Research07 Feb 2024
Nature

Volume: 626, P: 1066-1072
Intercalated amygdala clusters orchestrate a switch in fear state

Distinct clusters of inhibitory neurons in the mouse amygdala perform opposing roles in fear extinction.

Kenta M. Hagihara
Olena Bukalo
Andrew Holmes
Research26 May 2021
Nature

Volume: 594, P: 403-407
Brain mitochondrial diversity and network organization predict anxiety-like behavior in male mice

Brain mitochondria play crucial roles that influence cognition, yet their diversity is often overlooked. This study in mice identifies distinct mitochondrial phenotypes distributed as large-scale networks, accounting for a large portion of animal-to-animal behavioural variation.

Ayelet M. Rosenberg
Manish Saggar
Martin Picard
ResearchOpen Access10 Aug 2023
Nature Communications

Volume: 14, P: 1-19
An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence

Lee et al. report an engineered IgG1 Fc domain that behaves like an hFcRn binding pH toggle switch. The authors show that this new half-life extension Fc domain confers improved pharmacokinetics in new humanized knock-in mouse strains that recapitulate the key processes for antibody persistence in circulation.

Chang-Han Lee
Tae Hyun Kang
George Georgiou
ResearchOpen Access06 Nov 2019
Nature Communications

Volume: 10, P: 1-11
Publisher Correction: An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence

Chang-Han Lee
Tae Hyun Kang
George Georgiou
Amendments and CorrectionsOpen Access26 Nov 2019
Nature Communications

Volume: 10, P: 1
Genetic correlation between amyotrophic lateral sclerosis and schizophrenia

Relatives of patients with amyotrophic lateral sclerosis have an unexpectedly high incidence of schizophrenia. Here, the authors show a genetic link between the two conditions, suggesting shared neurobiological mechanisms.

Russell L. McLaughlin
Dick Schijven
Michael C. O’Donovan
ResearchOpen Access21 Mar 2017
Nature Communications

Volume: 8, P: 1-12
Rethinking wastewater risks and monitoring in light of the COVID-19 pandemic

Converging evidence indicates that SARS-CoVs are present in wastewater for several days with potential health risks. This Review analyses knowledge about such risks as well as the potential spread of SARS-CoVs in waterborne, waterborne–aerosolized and waterborne–foodborne pathways during a pandemic.

Anne Bogler
Aaron Packman
Edo Bar-Zeev
Reviews19 Aug 2020
Nature Sustainability

Volume: 3, P: 981-990
Identification of a novel gene regulating amygdala-mediated fear extinction

Ozge Gunduz-Cinar
Emma Brockway
Andrew Holmes
ResearchOpen Access08 Jan 2018
Molecular Psychiatry

Volume: 24, P: 601-612
Label-free biosensing with singular-phase-enhanced lateral position shift based on atomically thin plasmonic nanomaterials

We developed a novel label-free plasmonic biosensing configuration for sub-femtomolar (10⁻¹⁶ M) small molecule detection with an ultra-high sensitivity of 1.72 × 10⁸ nm RIU⁻¹ and a large figure of merit (FOM).

Shaodi Zhu
Rodolphe Jaffiol
Shuwen Zeng
ResearchOpen Access01 Jan 2024
Light: Science & Applications

Volume: 13, P: 1-13
Significant contribution of large BRCA1 gene rearrangements in 120 French breast and ovarian cancer families

Sophie Gad
Virginie Caux-Moncoutier
Dominique Stoppa-Lyonnet
Research02 Oct 2002
Oncogene

Volume: 21, P: 6841-6847

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Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes

A distinct cortical code for socially learned threat

Intercalated amygdala clusters orchestrate a switch in fear state

Brain mitochondrial diversity and network organization predict anxiety-like behavior in male mice

An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence

Publisher Correction: An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence

Genetic correlation between amyotrophic lateral sclerosis and schizophrenia

Rethinking wastewater risks and monitoring in light of the COVID-19 pandemic

Identification of a novel gene regulating amygdala-mediated fear extinction

Label-free biosensing with singular-phase-enhanced lateral position shift based on atomically thin plasmonic nanomaterials

Significant contribution of large BRCA1 gene rearrangements in 120 French breast and ovarian cancer families

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