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Showing 1–2 of 2 results
Advanced filters: Author: Aaron Mitchell-Dick Clear advanced filters

  • This protocol provides structure-guided capsid library approaches to evolve new adeno-associated viral vectors for enhanced CNS gene delivery with altered tissue tropism, higher transduction efficiency and the ability to evade pre-existing humoral immunity.

    • Trevor J. Gonzalez
    • Aaron Mitchell-Dick
    • Aravind Asokan
    Protocols
    Nature Protocols
    Volume: 18, P: 3413-3459

  • The ability to edit large stretches of mRNA transcripts remains a significant challenge. Here, the authors demonstrate that CRISPR-Cas13 systems can be repurposed to assist trans-splicing of exogenous RNA fragments into an endogenous pre-mRNA transcript, a method termed CRISPR Assisted mRNA Fragment Trans-splicing (CRAFT).

    • David N. Fiflis
    • Nicolas A. Rey
    • Aravind Asokan
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14