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Showing 1–6 of 6 results
Advanced filters: Author: Aaron Oldre Clear advanced filters

  • Combined patch clamp recording, biocytin staining and single-cell RNA-sequencing of human neurocortical neurons shows an expansion of glutamatergic neuron types relative to mouse that characterizes the greater complexity of the human neocortex.

    • Jim Berg
    • Staci A. Sorensen
    • Ed S. Lein
    ResearchOpen Access
    Nature
    Volume: 598, P: 151-158

  • A spatially resolved transcriptional atlas of the mid-gestational developing human brain has been created using laser-capture microdissection and microarray technology, providing a comprehensive reference resource which also enables new hypotheses about the nature of human brain evolution and the origins of neurodevelopmental disorders.

    • Jeremy A. Miller
    • Song-Lin Ding
    • Ed S. Lein
    Research
    Nature
    Volume: 508, P: 199-206

  • RNA-sequencing analysis of cells in the human cortex enabled identification of diverse cell types, revealing well-conserved architecture and homologous cell types as well as extensive differences when compared with datasets covering the analogous region of the mouse brain.

    • Rebecca D. Hodge
    • Trygve E. Bakken
    • Ed S. Lein
    Research
    Nature
    Volume: 573, P: 61-68

  • A high-resolution gene expression atlas of prenatal and postnatal brain development of rhesus monkey charts global transcriptional dynamics in relation to brain maturation, while comparative analysis reveals human-specific gene trajectories; candidate risk genes associated with human neurodevelopmental disorders tend to be co-expressed in disease-specific patterns in the developing monkey neocortex.

    • Trygve E. Bakken
    • Jeremy A. Miller
    • Ed S. Lein
    Research
    Nature
    Volume: 535, P: 367-375