Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–27 of 27 results
Advanced filters: Author: Aaron W. Lawson Clear advanced filters

  • Myocardial contractile force and intracardiac hemodynamic shear stress coordinate the initiation of trabeculation in heart development. Here, the authors report that radially aligned myocardial strain activates snai1b+/Notch− cardiomyocytes, initiating delamination for trabeculation.

    • Jing Wang
    • Aaron L. Brown
    • Tzung K. Hsiai
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • This protocol presents a versatile approach for the expression and purification of diverse recombinant protein complexes for structural studies, leveraging transient expression in Nicotiana benthamiana leaves to achieve high yield and purity.

    • Aaron W. Lawson
    • Arthur Macha
    • Paul Schulze-Lefert
    Protocols
    Nature Protocols
    P: 1-20

  • Analyses of imputed ancient genomes and of samples from the UK Biobank indicate that ancient selection and migration were large contributors to the distribution of phenotypic diversity in present-day Europeans.

    • Evan K. Irving-Pease
    • Alba Refoyo-Martínez
    • Eske Willerslev
    ResearchOpen Access
    Nature
    Volume: 625, P: 312-320

  • Evolutionary conservation of plant receptor structure allowed for generation of new variants of wheat and barley nucleotide-binding leucine-rich repeat receptors (NLRs) that recognize AvrSr35 of the wheat stem rust pathogen, supporting proof of principle for structure-based engineering of NLRs for crop improvement.

    • Alexander Förderer
    • Ertong Li
    • Jijie Chai
    ResearchOpen Access
    Nature
    Volume: 610, P: 532-539

  • An analysis involving the shotgun sequencing of more than 300 ancient genomes from Eurasia reveals a deep east–west genetic divide from the Black Sea to the Baltic, and provides insight into the distinct effects of the Neolithic transition on either side of this boundary.

    • Morten E. Allentoft
    • Martin Sikora
    • Eske Willerslev
    ResearchOpen Access
    Nature
    Volume: 625, P: 301-311

  • The authors develop a new oxide-dispersion-strengthened NiCoCr-based alloy using a model-driven alloy design approach and laser-based additive manufacturing, showing how such designs can provide superior compositions using far fewer resources than previous methods.

    • Timothy M. Smith
    • Christopher A. Kantzos
    • John W. Lawson
    ResearchOpen Access
    Nature
    Volume: 617, P: 513-518

  • Integrated data, including 100 human genomes from the Mesolithic, Neolithic and Early Bronze Age periods show that two major population turnovers occurred over just 1,000 years in Neolithic Denmark, resulting in dramatic changes in the genes, diet and physical appearance of the local people, as well as the landscape in which they lived.

    • Morten E. Allentoft
    • Martin Sikora
    • Eske Willerslev
    ResearchOpen Access
    Nature
    Volume: 625, P: 329-337

  • Cryo-electron microscopy reveals that the tomato immune receptor NRC2 forms oligomers to stabilize its inactive state and sequester it from activation, with inositol phosphates acting as immunoregulatory cofactors.

    • Shoucai Ma
    • Chunpeng An
    • Jijie Chai
    ResearchOpen Access
    Nature
    Volume: 632, P: 869-876

  • Low read depth sequencing of whole genomes and high read depth exomes of nearly 10,000 extensively phenotyped individuals are combined to help characterize novel sequence variants, generate a highly accurate imputation reference panel and identify novel alleles associated with lipid-related traits; in addition to describing population structure and providing functional annotation of rare and low-frequency variants the authors use the data to estimate the benefits of sequencing for association studies.

    • Klaudia Walter
    • Josine L. Min
    • Weihua Zhang
    ResearchOpen Access
    Nature
    Volume: 526, P: 82-90

  • Fine-scale estimates of the prevalence of HIV in adults across sub-Saharan Africa reveal substantial within-country variation and local differences in both the direction and rate of change in the prevalence of HIV between 2000 and 2017.

    • Laura Dwyer-Lindgren
    • Michael A. Cork
    • Simon I. Hay
    ResearchOpen Access
    Nature
    Volume: 570, P: 189-193

  • Levels of circulating thyrotropin and free thyroxine reflect thyroid function, however, their genetic underpinnings remain poorly understood. Taylor et al. take advantage of whole-genome sequence data from cohorts within the UK10K project to identify novel variants associated with these traits.

    • Peter N. Taylor
    • Eleonora Porcu
    • Pingbo Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-11

  • Dual recognition specificity of an MLA immune receptor in barley demonstrates that the deployment of mildew-resistant cultivars by plant breeders has unintentionally affected nonhost resistance to wheat stripe rust.

    • Isabel M. L. Saur
    • Aaron W. Lawson
    • Paul Schulze-Lefert
    News & Views
    Nature Plants
    Volume: 8, P: 100-101

  • Imputation uses genotype information from SNP arrays to infer the genotypes of missing markers. Here, the authors show that an imputation reference panel derived from whole-genome sequencing of 3,781 samples from the UK10K project improves the imputation accuracy and coverage of low frequency variants compared to existing methods.

    • Jie Huang
    • Bryan Howie
    • Nicole Soranzo
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-9

  • Population-based genome sequencing provides an increasingly rich resource for the identification of low-frequency, large effect variants associated with clinically important phenotypes. Timpson et al. use UK10K data to identify a variant of the APOC3gene strongly associated with plasma triglyceride levels.

    • Nicholas J. Timpson
    • Klaudia Walter
    • Hou-Feng Zheng
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-11

  • Size and shape of the brain are, among others, influenced by the dimensions of the skull. Here, the authors report genome-wide association studies for head circumference and intracranial volume in children and adults and the identification of nine common or low-frequency variants associated with these traits.

    • Simon Haworth
    • Chin Yang Shapland
    • Beate St Pourcain
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16

  • Blum et al. combine computational and experimental methods to study the long-term development of tissue engineered vascular grafts in a lamb model. The authors demonstrate that the grafts undergo growth and remodeling, evolving to mimic the characteristics and function of a native blood vessel.

    • Kevin M. Blum
    • Jacob C. Zbinden
    • Christopher K. Breuer
    ResearchOpen Access
    Communications Medicine
    Volume: 2, P: 1-21

  • An orally available VHL-ERα PROTAC was developed that showed excellent degradation in vitro. When dosing in vivo, the degradation of ERα was lower than expected, due to competitive binding at the ERα binding site between the PROTAC and a linker metabolite.

    • Thomas G. Hayhow
    • Beth Williamson
    • Claire Crafter
    ResearchOpen Access
    Communications Biology
    Volume: 7, P: 1-17

  • Ma, Hernandez et al develop a 3D culture-transplant system to enable studies of cancer metastasis using patient-derived xenograft (PDX) tumor cells. Using this system, they find that OXPHOS inhibition attenuates the lung metastatic capacity of breast cancer cells and that overexpression of the metabolic enzyme NME1 increases lung metastasis.

    • Dennis Ma
    • Grace A. Hernandez
    • Devon A. Lawson
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-15