Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–9 of 9 results
Advanced filters: Author: Aaron W. Michels Clear advanced filters

  • Severe cutaneous adverse reactions (SCAR) is a T cell-mediated, potentially lethal drug hypersensitivity (DH). Here, the authors identify a carbamazepine-specific TCR common among patients with carbamazepine-induced SCAR that confers SCAR-like pathology in mice upon carbamazepine exposure, thereby implicating specific TCRs in DH etiology.

    • Ren-You Pan
    • Mu-Tzu Chu
    • Shuen-Iu Hung
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • The autoimmune polyglandular syndromes (APS), a combination of endocrine and nonendocrine autoimmune diseases, differ in their component diseases and in the immunologic features of their pathogenesis. This Review discusses the genetic basis of the three main syndromes—APS-1, APS-2 and IPEX (immune dysfunction, polyendocrinopathy, enteropathy, X-linked) syndrome—with an emphasis on the mechanisms of autoimmunity, and presents currently available treatment strategies for their underlying autoimmune disorders.

    • Aaron W. Michels
    • Peter A. Gottlieb
    Reviews
    Nature Reviews Endocrinology
    Volume: 6, P: 270-277

  • The structure of the bacterial toxin BinAB, which is used to combat mosquito-borne diseases, reveals pH-sensitive switches and carbohydrate-binding modules that may contribute to the larvicidal function of the toxin.

    • Jacques-Philippe Colletier
    • Michael R. Sawaya
    • David S. Eisenberg
    Research
    Nature
    Volume: 539, P: 43-47

  • A new sample-delivery method for serial X-ray crystallography exploits the full repetition rate of the X-ray free-electron laser at the LCLS facility, thus enabling efficient, high-speed data collection to solve the three-dimensional structures of viruses.

    • Philip Roedig
    • Helen M Ginn
    • Alke Meents
    Research
    Nature Methods
    Volume: 14, P: 805-810

  • In multi-layered epithelia tight junctions (TJ) are confined to the most suprabasal viable layer. Here the authors show that this is regulated by ubiquitously localized E-cadherin tuning junctional tension and EGFR activity to inhibit TJ formation in lower layers while promoting TJ stability in the granular layer 2.

    • Matthias Rübsam
    • Aaron F. Mertz
    • Carien M. Niessen
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16