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Showing 1–4 of 4 results
Advanced filters: Author: Aarron T Willingham Clear advanced filters

  • As part of the modENCODE initiative, which aims to characterize functional DNA elements in D. melanogaster and C. elegans, this study uses RNA-Seq, tiling microarrays and cDNA sequencing to explore the transcriptome in 30 distinct developmental stages of the fruitfly. Among the results are scores of new genes, coding and non-coding transcripts, as well as splicing and editing events.

    • Brenton R. Graveley
    • Angela N. Brooks
    • Susan E. Celniker
    Research
    Nature
    Volume: 471, P: 473-479

  • Genome-wide analyses of transcriptional output in eukaryotes have revealed an unanticipated transcriptome complexity. These findings imply a complex, interleaved genomic organization, in which individual sequences carry multiple and overlapping informational content. The authors discuss the evidence for, and functional and evolutionary consequences of, this organization.

    • Philipp Kapranov
    • Aarron T. Willingham
    • Thomas R. Gingeras
    Reviews
    Nature Reviews Genetics
    Volume: 8, P: 413-423

  • The transcriptomes of eukaryotic cells are unexpectedly complex, with virtually the entire non-repeat portions of many genomes being transcribed. Using deep sequencing, this study reveals that a remarkable breadth of RNA species that come from both within annotated genes and from unannotated intergenic regions in human cells. Many of these small RNAs possess cap structures and seem to be processed from mature mRNAs resulting in populations of long and short RNAs with capped 5' ends that coincide.

    • Katalin Fejes-Toth
    • Vihra Sotirova
    • Thomas R. Gingeras
    Research
    Nature
    Volume: 457, P: 1028-1032