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Showing 1–6 of 6 results
Advanced filters: Author: Aarthi Talla Clear advanced filters

  • A follow-up analysis of a clinical trial that evaluated anti-PD-1 therapy in patients with cancer who are living with HIV provides mechanistic insights into transcriptomic, cellular and cytokine changes related to immune checkpoint inhibitor treatment and identifies a signature associated with clinical response.

    • Aarthi Talla
    • Joao L. L. C. Azevedo
    • Rafick-Pierre Sekaly
    ResearchOpen Access
    Nature Medicine
    Volume: 32, P: 505-517

  • Long COVID or post-acute sequelae of SARS-CoV-2 is defined by persisting chronic symptoms following acute SARS-CoV-2 infection but represent an aetiologically diverse group of disorders. Here authors identify molecularly distinct subtypes, including a form with persistent inflammation, via longitudinal analysis of serum proteome.

    • Aarthi Talla
    • Suhas V. Vasaikar
    • Troy R. Torgerson
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • The response to respiratory virus exposure can currently not be predicted by pre- or early post-exposure molecular signatures. Here, the authors conduct a community-based analysis of blood gene expression from healthy individuals exposed to respiratory viruses and provide predictive models and biological insight into the physiological response.

    • Slim Fourati
    • Aarthi Talla
    • Solveig K. Sieberts
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11

  • The RV144 vaccine trial showed reduced risk of HIV-1 acquisition, but mechanisms underlying protection are poorly understood. Here, Fourati et al. assess the transcriptomic profile of blood collected from 223 vaccinees and 40 placebo recipients and identify IRF7 as a mediator of protection.

    • Slim Fourati
    • Susan Pereira Ribeiro
    • Rafick-Pierre Sékaly
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • The analysis of longitudinal bulk and single-cell multi-omics data is a highly complex task. Here, the authors introduce PALMO, a software platform with five modules to analyse longitudinal bulk and single-cell multi-omics data, which is extensively tested in external datasets that include multiple omics modalities.

    • Suhas V. Vasaikar
    • Adam K. Savage
    • Xiao-jun Li
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • Ageing is associated with poor responses to vaccines but the underlying mechanism remains unclear. Here the authors use a systems-based approach to define molecular signatures present before vaccination that correlate with non-responsiveness to hepatitis B vaccination in healthy, elderly adults.

    • Slim Fourati
    • Razvan Cristescu
    • Rafick-Pierre Sékaly
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12