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A human-serum-free medium can induce more infectious P. falciparum gametocytes than a conventional human-serum-containing medium

Kazutoyo Miura
Bingbing Deng
Carole A. Long
ResearchOpen Access27 Sept 2024
Scientific Reports

Volume: 14, P: 1-7
Neutralizing and interfering human antibodies define the structural and mechanistic basis for antigenic diversion

The Plasmodium falciparum Merozoite Surface Protein 1 (MSP-1) is a prime vaccine candidate for malaria. Here, the authors structurally and functionally characterise a panel of naturally acquired MSP-1 specific antibodies to identify one with potent broadly neutralising activity and better understand immune evasion mechanisms.

Palak N. Patel
Thayne H. Dickey
Niraj H. Tolia
ResearchOpen Access06 Oct 2022
Nature Communications

Volume: 13, P: 1-11
Structure guided mimicry of an essential P. falciparum receptor-ligand complex enhances cross neutralizing antibodies

The AMA1-RON2 complex is important for Plasmodium falciparum invasion and a potential vaccine target. Here the authors engineer a fusion protein of AMA1 and RON2 loop that mimics the receptor-ligand complex and show that it induces antibodies that neutralize non-vaccine type parasites.

Sean Yanik
Varsha Venkatesh
Prakash Srinivasan
ResearchOpen Access21 Sept 2023
Nature Communications

Volume: 14, P: 1-11
Structure-based design of a strain transcending AMA1-RON2L malaria vaccine

Here the authors use structure-based design to engineer a single component immunogen that mimics the malaria parasite AMA1-RON2 complex required for invasion of host cells, and show that it elicits a potent strain-transcending antibody response in rats.

Palak N. Patel
Thayne H. Dickey
Niraj H. Tolia
ResearchOpen Access02 Sept 2023
Nature Communications

Volume: 14, P: 1-16
A defined mechanistic correlate of protection against Plasmodium falciparum malaria in non-human primates

Proof of protection against blood-stage P. falciparum malaria by a single immunological mechanism has been elusive. Here, using engineered anti-PfRH5 chimeric monoclonal antibodies in non-human primates, the authors show that high levels of merozoite-neutralizing antibodies can achieve protection.

Alexander D. Douglas
G. Christian Baldeviano
Simon J. Draper
ResearchOpen Access26 Apr 2019
Nature Communications

Volume: 10, P: 1-8
Elucidating functional epitopes within the N-terminal region of malaria transmission blocking vaccine antigen Pfs230

Kazutoyo Miura
Eizo Takashima
Takafumi Tsuboi
ResearchOpen Access13 Jan 2022
npj Vaccines

Volume: 7, P: 1-10
Bliss' and Loewe's additive and synergistic effects in Plasmodium falciparum growth inhibition by AMA1-RON2L, RH5, RIPR and CyRPA antibody combinations

Yvonne Azasi
Shannon K. Gallagher
Kazutoyo Miura
ResearchOpen Access16 Jul 2020
Scientific Reports

Volume: 10, P: 1-12
A malaria vaccine protects Aotus monkeys against virulent Plasmodium falciparum infection

Prakash Srinivasan
G. Christian Baldeviano
Louis H. Miller
ResearchOpen Access22 May 2017
npj Vaccines

Volume: 2, P: 1-10
Immunoscreening of Plasmodium falciparum proteins expressed in a wheat germ cell-free system reveals a novel malaria vaccine candidate

Masayuki Morita
Eizo Takashima
Takafumi Tsuboi
ResearchOpen Access05 Apr 2017
Scientific Reports

Volume: 7, P: 1-8

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A human-serum-free medium can induce more infectious P. falciparum gametocytes than a conventional human-serum-containing medium

Neutralizing and interfering human antibodies define the structural and mechanistic basis for antigenic diversion

Structure guided mimicry of an essential P. falciparum receptor-ligand complex enhances cross neutralizing antibodies

Structure-based design of a strain transcending AMA1-RON2L malaria vaccine

A defined mechanistic correlate of protection against Plasmodium falciparum malaria in non-human primates

Elucidating functional epitopes within the N-terminal region of malaria transmission blocking vaccine antigen Pfs230

Bliss' and Loewe's additive and synergistic effects in Plasmodium falciparum growth inhibition by AMA1-RON2L, RH5, RIPR and CyRPA antibody combinations

A malaria vaccine protects Aotus monkeys against virulent Plasmodium falciparum infection

Immunoscreening of Plasmodium falciparum proteins expressed in a wheat germ cell-free system reveals a novel malaria vaccine candidate

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