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Plasmodium vivax binds host CD98hc (SLC3A2) to enter immature red blood cells

CD98 heavy chain (CD98) is identified as a reticulocyte-specific receptor for the Plasmodium vivax PvRBP2a ligand.

Benoît Malleret
Abbas El Sahili
Laurent Rénia
Research22 Jul 2021
Nature Microbiology

Volume: 6, P: 991-999
Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A*11:01

Anti-human leukocyte antigen (HLA) antibodies are important mediators of alloresponses, but structural insights on antibody:HLA interaction are still lacking. Here the authors provide a 2.4 Å structure of antibody:HLA complex, and also analyse HLA features important for other HLA-interacting molecules, to enhance our understanding of alloimmunity.

Yue Gu
Yee Hwa Wong
Paul A. MacAry
ResearchOpen Access21 Feb 2019
Nature Communications

Volume: 10, P: 1-11
Engineering SARS-CoV-2 specific cocktail antibodies into a bispecific format improves neutralizing potency and breadth

Bispecific antibodies can have advantages compared to antibody cocktails. Here, the authors engineer and characterize two different approaches for generating bispecific SARS-CoV-2 specific antibodies and find that only one design increases antigen-binding and virus neutralizing activities.

Zhiqiang Ku
Xuping Xie
Zhiqiang An
ResearchOpen Access22 Sept 2022
Nature Communications

Volume: 13, P: 1-12
Structure of the human metapneumovirus polymerase phosphoprotein complex

A cryo-electron microscopy reconstruction shows the ring-shaped structure of the polymerase and capping domains of the L protein bound to a tetramer of phosphoprotein P of the human metapneumovirus.

Junhua Pan
Xinlei Qian
Julien Lescar
Research07 Nov 2019
Nature

Volume: 577, P: 275-279
Allosteric pyruvate kinase-based “logic gate” synergistically senses energy and sugar levels in Mycobacterium tuberculosis

Pyruvate kinase (PYK) controls glycolytic flux. Here, the authors combine biochemical, structural and computational modelling studies to characterize the allosteric mechanisms regulating Mycobacterium tuberculosis PYK activity and show that AMP and glucose-6-phosphate are synergistic allosteric activators of the enzyme.

Wenhe Zhong
Liang Cui
Peter C. Dedon
ResearchOpen Access07 Dec 2017
Nature Communications

Volume: 8, P: 1-14
The protein kinase CK2 catalytic domain from Plasmodium falciparum: crystal structure, tyrosine kinase activity and inhibition

David Ruiz-Carrillo
Jianqing Lin
Julien Lescar
ResearchOpen Access09 May 2018
Scientific Reports

Volume: 8, P: 1-12
Inhibition of falcilysin from Plasmodium falciparum by interference with its closed-to-open dynamic transition

The antimalarial drug MK-4815 shifts falcilysin to a closed state inhibiting its proteolytic cycle, which provides insights for designing potent falcilysin inhibitors to combat malaria.

Jianqing Lin
Xinfu Yan
Julien Lescar
ResearchOpen Access31 Aug 2024
Communications Biology

Volume: 7, P: 1-14
Structural basis for high specificity of octopine binding in the plant pathogen Agrobacterium tumefaciens

Armelle Vigouroux
Abbas El Sahili
Solange Moréra
ResearchOpen Access21 Dec 2017
Scientific Reports

Volume: 7, P: 1-13
Fitness costs restrict niche expansion by generalist niche-constructing pathogens

Julien Lang
Armelle Vigouroux
Denis Faure
Research01 Nov 2016
The ISME Journal

Volume: 11, P: 374-385

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Plasmodium vivax binds host CD98hc (SLC3A2) to enter immature red blood cells

Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A*11:01

Engineering SARS-CoV-2 specific cocktail antibodies into a bispecific format improves neutralizing potency and breadth

Structure of the human metapneumovirus polymerase phosphoprotein complex

Allosteric pyruvate kinase-based “logic gate” synergistically senses energy and sugar levels in Mycobacterium tuberculosis

The protein kinase CK2 catalytic domain from Plasmodium falciparum: crystal structure, tyrosine kinase activity and inhibition

Inhibition of falcilysin from Plasmodium falciparum by interference with its closed-to-open dynamic transition

Structural basis for high specificity of octopine binding in the plant pathogen Agrobacterium tumefaciens

Fitness costs restrict niche expansion by generalist niche-constructing pathogens

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