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Retraction Note: Pericyte degeneration causes white matter dysfunction in the mouse central nervous system

Axel Montagne
Angeliki M. Nikolakopoulou
Berislav V. Zlokovic
Amendments and Corrections05 Apr 2024
Nature Medicine

Volume: 30, P: 1215
RETRACTED ARTICLE: Pericyte loss influences Alzheimer-like neurodegeneration in mice

Pericytes are cells in the blood–brain barrier that degenerate with the onset of Alzheimer's disease. Here, Sagare et al. show that pericyte loss contributes to disease onset by promoting amyloid-beta accumulation, tau pathology and early loss of neuronal cells.

Abhay P. Sagare
Robert D. Bell
Berislav V. Zlokovic
ResearchOpen Access13 Dec 2013
Nature Communications

Volume: 4, P: 1-14
Author Correction: APOE4 accelerates advanced-stage vascular and neurodegenerative disorder in old Alzheimer’s mice via cyclophilin A independently of amyloid-β

Axel Montagne
Angeliki M. Nikolakopoulou
Berislav V. Zlokovic
Amendments and Corrections29 Jun 2021
Nature Aging

Volume: 1, P: 624
Retraction Note: Pericyte loss influences Alzheimer-like neurodegeneration in mice

Abhay P. Sagare
Robert D. Bell
Berislav V. Zlokovic
Amendments and CorrectionsOpen Access03 Apr 2024
Nature Communications

Volume: 15, P: 1
Author Correction: Pericyte loss influences Alzheimer-like neurodegeneration in mice

Abhay P. Sagare
Robert D. Bell
Berislav V. Zlokovic
Amendments and CorrectionsOpen Access03 Oct 2023
Nature Communications

Volume: 14, P: 1-3
Clearance of amyloid-β by circulating lipoprotein receptors

Abhay Sagare
Rashid Deane
Berislav V Zlokovic
Research12 Aug 2007
Nature Medicine

Volume: 13, P: 1029-1031
APOE4 accelerates advanced-stage vascular and neurodegenerative disorder in old Alzheimer’s mice via cyclophilin A independently of amyloid-β

This study shows that APOE4, one of the largest genetic risk factors for Alzheimer’s disease, promotes advanced-stage vascular dysfunction and neurodegeneration in old mice via activation of the cyclophilin A pathway in pericytes and independently of the presence of amyloid-β.

Axel Montagne
Angeliki M. Nikolakopoulou
Berislav V. Zlokovic
Research14 Jun 2021
Nature Aging

Volume: 1, P: 506-520
Author Correction: Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

Robert D. Bell
Ethan A. Winkler
Berislav V. Zlokovic
Amendments and Corrections05 May 2023
Nature

Volume: 617, P: E12
Author Correction: Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance

Zhen Zhao
Abhay P. Sagare
Berislav V. Zlokovic
Amendments and Corrections20 Nov 2023
Nature Neuroscience

Volume: 27, P: 208
APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline

Breakdown of the blood–brain barrier in individuals carrying the ε4 allele of the APOE gene, but not the ε3 allele, increases with and predicts cognitive impairment and is independent of amyloid β or tau pathology.

Axel Montagne
Daniel A. Nation
Berislav V. Zlokovic
Research29 Apr 2020
Nature

Volume: 581, P: 71-76
GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration

Winkler et al. show that the glucose transporter GLUT1 in brain endothelium is necessary for the maintenance of proper brain capillary networks and blood-brain barrier integrity. The study also shows that loss of GLUT1 in a mouse model of Alzheimer's disease accelerates BBB breakdown, perfusion and metabolic stress resulting in behavioral deficits, elevated amyloid beta levels and neurodegeneration.

Ethan A Winkler
Yoichiro Nishida
Berislav V Zlokovic
Research02 Mar 2015
Nature Neuroscience

Volume: 18, P: 521-530
Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance

Zhao et al. report that brain vessels have a major role in clearing Alzheimer's disease–related toxin Aβ from brain and show that PICALM gene product and its variant associated with an increased risk for Alzheimer's disease inactivate an Aβ clearance system in blood vessels, leading to Aβ brain accumulation and cognitive impairment.

Zhen Zhao
Abhay P Sagare
Berislav V Zlokovic
Research25 May 2015
Nature Neuroscience

Volume: 18, P: 978-987
ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration

Zhihui Zhong
Rashid Deane
Berislav V Zlokovic
Research16 Mar 2008
Nature Neuroscience

Volume: 11, P: 420-422
Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

The APOE4-mediated proinflammatory pathway is shown to initiate blood–brain barrier breakdown and resulting neurodegeneration in transgenic mice.

Robert D. Bell
Ethan A. Winkler
Berislav V. Zlokovic
Research16 May 2012
Nature

Volume: 485, P: 512-516
Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss

Using pericyte-specific Cre and ablation mouse lines, the authors show that loss of brain pericytes leads to circulatory failure and reduced pleiotrophin causing rapid neuron loss. These findings link pericyte loss to a rapid neurodegeneration cascade.

Angeliki M. Nikolakopoulou
Axel Montagne
Berislav V. Zlokovic
Research24 Jun 2019
Nature Neuroscience

Volume: 22, P: 1089-1098
SRF and myocardin regulate LRP-mediated amyloid-β clearance in brain vascular cells

Accumulation of amyloid β peptide in cerebral blood vessels has been linked to brain dysfunction. SRF and myocardin transcription factors are induced by cerebral hypoxia and reduce amyloid clearance by regulating SREBP2, a transcriptional repressor that acts on the amyloid aggregate clearance factor LRP1.

Robert D. Bell
Rashid Deane
Berislav V. Zlokovic
Research21 Dec 2008
Nature Cell Biology

Volume: 11, P: 143-153
Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease

Zhenhua Wu
Huang Guo
Berislav V Zlokovic
Research14 Aug 2005
Nature Medicine

Volume: 11, P: 959-965
RETRACTED ARTICLE: Pericyte degeneration causes white matter dysfunction in the mouse central nervous system

Degeneration of pericytes causes toxic fibrin(ogen) accumulation, cell death and microcirculation dysfunction in CNS white-matter axon tracts.

Axel Montagne
Angeliki M Nikolakopoulou
Berislav V Zlokovic
Research05 Feb 2018
Nature Medicine

Volume: 24, P: 326-337
Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction

Neuroimaging and cerebrospinal fluid analyses in humans reveal that loss of blood–brain barrier integrity and brain capillary pericyte damage are early biomarkers of cognitive impairment that occur independently of changes in amyloid-β and tau.

Daniel A. Nation
Melanie D. Sweeney
Berislav V. Zlokovic
Research14 Jan 2019
Nature Medicine

Volume: 25, P: 270-276
Molecular biomarkers for vascular cognitive impairment and dementia

Vascular cognitive impairment and dementia is the second most common cause of dementia after Alzheimer disease. In this Review, the authors examine the potential of key molecules in the pathophysiology as biomarkers of vascular cognitive impairment and dementia and consider the challenges of clinical translation.

Satoshi Hosoki
Gurpreet K. Hansra
Perminder S. Sachdev
Reviews13 Nov 2023
Nature Reviews Neurology

Volume: 19, P: 737-753
Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

Here, Sweeney and colleagues focus on advanced neuroimaging evidence of blood–brain barrier (BBB) breakdown in several neurodegenerative disorders. The role of the ageing cerebrovascular system in neurodegeneration and dementia and the implications of BBB dysfunction for treatment and drug delivery are also discussed.

Melanie D. Sweeney
Abhay P. Sagare
Berislav V. Zlokovic
Reviews29 Jan 2018
Nature Reviews Neurology

Volume: 14, P: 133-150

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Retraction Note: Pericyte degeneration causes white matter dysfunction in the mouse central nervous system

RETRACTED ARTICLE: Pericyte loss influences Alzheimer-like neurodegeneration in mice

Author Correction: APOE4 accelerates advanced-stage vascular and neurodegenerative disorder in old Alzheimer’s mice via cyclophilin A independently of amyloid-β

Retraction Note: Pericyte loss influences Alzheimer-like neurodegeneration in mice

Author Correction: Pericyte loss influences Alzheimer-like neurodegeneration in mice

Clearance of amyloid-β by circulating lipoprotein receptors

APOE4 accelerates advanced-stage vascular and neurodegenerative disorder in old Alzheimer’s mice via cyclophilin A independently of amyloid-β

Author Correction: Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

Author Correction: Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance

APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline

GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration

Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance

ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss

SRF and myocardin regulate LRP-mediated amyloid-β clearance in brain vascular cells

Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease

RETRACTED ARTICLE: Pericyte degeneration causes white matter dysfunction in the mouse central nervous system

Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction

Molecular biomarkers for vascular cognitive impairment and dementia

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

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