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Phylogeographical analysis of the dominant multidrug-resistant H58 clade of Salmonella Typhi identifies inter- and intracontinental transmission events

Vanessa Wong and colleagues report whole-genome sequencing of 1,832 Salmonella enterica serovar Typhi isolates from 63 endemic countries. They identify mutations that define the multidrug resistant (MDR) H58 lineage and report numerous inter- and intracontinental transmissions of this lineage as well as an ongoing MDR typhoid epidemic in Africa.

Vanessa K Wong
Stephen Baker
Gordon Dougan
Research11 May 2015
Nature Genetics

Volume: 47, P: 632-639
Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma

Chiea Chuen Khor, Tin Aung and colleagues report the results of a large genome-wide association study of primary angle closure glaucoma. They identify five new susceptibility loci and provide insights into disease pathogenesis.

Chiea Chuen Khor
Tan Do
Tin Aung
Research04 Apr 2016
Nature Genetics

Volume: 48, P: 556-562
Variation at HLA-DRB1 is associated with resistance to enteric fever

Sarah Dunstan, Chiea Chuen Khor and colleagues identify common variants in the HLA-DRB1 region associated with resistance to enteric fever. Individuals carrying the protective variants exhibit roughly five-fold higher resistance against developing this life-threatening infectious disease.

Sarah J Dunstan
Nguyen Thi Hue
Chiea Chuen Khor
Research10 Nov 2014
Nature Genetics

Volume: 46, P: 1333-1336
An extended genotyping framework for Salmonella enterica serovar Typhi, the cause of human typhoid

Typhoid fever is caused by Salmonella enterica serovar Typhi (S. Typhi). This study examines ∼2,000 clinical isolates of S. Typhi to show highly structured/geographically restricted genomes except rapidly disseminating H58 subclade, and design a genotyping framework for tracking the disease.

Vanessa K. Wong
Stephen Baker
Ben Amos
ResearchOpen Access05 Oct 2016
Nature Communications

Volume: 7, P: 1-11
Modelling Salmonella Typhi in high-density urban Blantyre neighbourhood, Malawi, using point pattern methods

Jessie J. Khaki
James E. Meiring
Emanuele Giorgi
ResearchOpen Access26 Jul 2024
Scientific Reports

Volume: 14, P: 1-10
Direct inference and control of genetic population structure from RNA sequencing data

RGStraP is a computational pipeline to estimate RNA-seq-based genetic principal components and assess whether these can be used to control for population structure in gene expression analyses.

Muhamad Fachrul
Abhilasha Karkey
Michael Inouye
ResearchOpen Access02 Aug 2023
Communications Biology

Volume: 6, P: 1-9
Aetiologies of Central Nervous System infections in adults in Kathmandu, Nepal: A prospective hospital-based study

Abhishek Giri
Amit Arjyal
Buddha Basnyat
ResearchOpen Access08 Aug 2013
Scientific Reports

Volume: 3, P: 1-7

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Phylogeographical analysis of the dominant multidrug-resistant H58 clade of Salmonella Typhi identifies inter- and intracontinental transmission events

Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma

Variation at HLA-DRB1 is associated with resistance to enteric fever

An extended genotyping framework for Salmonella enterica serovar Typhi, the cause of human typhoid

Modelling Salmonella Typhi in high-density urban Blantyre neighbourhood, Malawi, using point pattern methods

Direct inference and control of genetic population structure from RNA sequencing data

Aetiologies of Central Nervous System infections in adults in Kathmandu, Nepal: A prospective hospital-based study

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Phylogeographical analysis of the dominant multidrug-resistant H58 clade of Salmonella Typhi identifies inter- and intracontinental transmission events

Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma

Variation at HLA-DRB1 is associated with resistance to enteric fever

An extended genotyping framework for Salmonella enterica serovar Typhi, the cause of human typhoid

Modelling Salmonella Typhi in high-density urban Blantyre neighbourhood, Malawi, using point pattern methods

Direct inference and control of genetic population structure from RNA sequencing data

Aetiologies of Central Nervous System infections in adults in Kathmandu, Nepal: A prospective hospital-based study

Search

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