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Showing 1–2 of 2 results
Advanced filters: Author: Abhishek A. Bavle Clear advanced filters

  • In an exploratory analysis of the KEYNOTE-361 phase 3 trial that tested immunotherapy and chemotherapy in advanced urothelial carcinoma, different early circulating tumor DNA (ctDNA) dynamics were observed between the two treatments, and ctDNA levels were associated with response to pembrolizumab but not to chemotherapy.

    • Thomas Powles
    • Yen-Hwa Chang
    • Seyda Gunduz
    ResearchOpen Access
    Nature Medicine
    Volume: 30, P: 2508-2516

  • The genetic basis of clear cell sarcomas of the kidney is not well understood. In this study, Roy et al. perform whole-exome and RNA sequencing of these tumours and identify recurrent internal tandem duplications in BCOR, a key constituent of a variant polycomb repressive complex.

    • Angshumoy Roy
    • Vijetha Kumar
    • D. Williams Parsons
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-7