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Showing 1–6 of 6 results
Advanced filters: Author: Abhishek Singharoy Clear advanced filters

  • The EMDataResource Ligand Model Challenge aimed at assessing the reliability and reproducibility of modeling ligands bound to protein and protein–nucleic acid complexes in cryo-EM maps determined at near-atomic resolution. This analysis presents the results and recommends best practices for assessing cryo-EM structures of liganded macromolecules.

    • Catherine L. Lawson
    • Andriy Kryshtafovych
    • Wah Chiu
    Research
    Nature Methods
    Volume: 21, P: 1340-1348

  • There is a great interest in retrieving functional pathways from cryo-EM single-particle data. Here, the authors present an approach that combines cryo-EM with advanced data-analytical methods and molecular dynamics simulations to reveal the functional pathways traversed on experimentally derived energy landscapes using the ryanodine receptor type 1 as an example.

    • Ali Dashti
    • Ghoncheh Mashayekhi
    • Abbas Ourmazd
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • Voltage sensor domains (VSDs) transducer changes in the electrical field across cell membranes into conformational changes that alter the activation state of an effector domain. Structural and biophysical data on the VSD from Ci-VSP reveal the first view of this domain in the resting state, providing new insight into voltage-dependent structural transitions.

    • Qufei Li
    • Sherry Wanderling
    • Eduardo Perozo
    Research
    Nature Structural & Molecular Biology
    Volume: 21, P: 244-252