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Nature Methods (1)

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Advanced filters: Author: Abigail V. Sharrock Clear advanced filters

NTR 2.0: a rationally engineered prodrug-converting enzyme with substantially enhanced efficacy for targeted cell ablation

An engineered bacterial nitroreductase, NTR 2.0, improves chemically induced cell ablation, facilitating novel sustained ablation paradigms for testing the effects of chronic inflammation on regeneration, and modeling degenerative disease.

Abigail V. Sharrock
Timothy S. Mulligan
Jeff S. Mumm
Research07 Feb 2022
Nature Methods

Volume: 19, P: 205-215

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NTR 2.0: a rationally engineered prodrug-converting enzyme with substantially enhanced efficacy for targeted cell ablation

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