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An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient

An allosteric inhibitor of the proteolytic activity of the CBM signalosome complex scaffolding protein MALT1 acts as a pharmacological chaperone to stabilize a mutant MALT1 carried by an immunodeficient patient.

Jean Quancard
Theo Klein
Christopher M. Overall
Research28 Jan 2019
Nature Chemical Biology

Volume: 15, P: 304-313

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An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient

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