Nature Search

A systems-based approach to uterine fibroids identifies differential splicing associated with abnormal uterine bleeding

Wang, Philpott et al. perform integrative genomic, transcriptomic and proteomic analyses across fibroid, myometrium, and endometrium tissues to uncover mechanisms underlying uterine fibroid (UF) associated heavy menstrual bleeding. Signalling from MED12-mutated fibroids alters RNA splicing events in the endometrium.

Chen-Yi Wang
Martin Philpott
Adam P. Cribbs
ResearchOpen Access31 Jul 2025
Communications Medicine

Volume: 5, P: 1-16
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Large genome-wide meta-analysis of clinically diagnosed late-onset Alzheimer’s disease (LOAD) from 94,437 individuals identifies new LOAD risk loci and implicates Aβ formation, tau protein binding, immune response and lipid metabolism.

Brian W. Kunkle
Benjamin Grenier-Boley
Margaret A. Pericak-Vance
Research28 Feb 2019
Nature Genetics

Volume: 51, P: 414-430
Correcting PCR amplification errors in unique molecular identifiers to generate accurate numbers of sequencing molecules

This study introduces a method utilizing homotrimeric nucleotide blocks to achieve accurate counts of RNA molecules in both bulk and single-cell sequencing data.

Jianfeng Sun
Martin Philpott
Adam P. Cribbs
ResearchOpen Access05 Feb 2024
Nature Methods

Volume: 21, P: 401-405
New insights into the genetic etiology of Alzheimer’s disease and related dementias

Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

Céline Bellenguez
Fahri Küçükali
Jean-Charles Lambert
ResearchOpen Access04 Apr 2022
Nature Genetics

Volume: 54, P: 412-436
Nanopore sequencing of single-cell transcriptomes with scCOLOR-seq

Single-cell transcriptomes are accurately sequenced with error-tolerant barcodes.

Martin Philpott
Jonathan Watson
Adam P. Cribbs
ResearchOpen Access01 Jul 2021
Nature Biotechnology

Volume: 39, P: 1517-1520
Spatially and optically tailored 3D printing for highly miniaturized and integrated microfluidics

The ever-growing need for highly functional, compact, and integrated microfluidic devices often incurs lengthy and expensive manufacturing processes. Here, authors introduce a generalized 3D printing process that enables fast parallel fabrication of miniaturized, high resolution 3D components.

Jose L. Sanchez Noriega
Nicholas A. Chartrand
Gregory P. Nordin
ResearchOpen Access17 Sept 2021
Nature Communications

Volume: 12, P: 1-13
An essential role for the Zn²⁺ transporter ZIP7 in B cell development

Zinc is important for normal immunity but its mechanistic actions are poorly understood. Hambleton and colleagues identify defects in Zn²⁺ transport that underpin a novel human immunodeficiency characterized by loss of mature B cells.

Consuelo Anzilotti
David J. Swan
Sophie Hambleton
Research04 Feb 2019
Nature Immunology

Volume: 20, P: 350-361
Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming

A chromatin-focused chemical screen identified CBP/EP300 bromodomain inhibitors as enhancers of reprogramming. These inhibitors decrease histone H3 lysine 27 acetylation, chromatin accessibility and expression of somatic-specific genes.

Ayyub Ebrahimi
Kenan Sevinç
Tamer T. Önder
Research08 Apr 2019
Nature Chemical Biology

Volume: 15, P: 519-528
Chromatin-focused genetic and chemical screens identify BRPF1 as a targetable vulnerability in Taxol-resistant triple-negative breast cancer

Ozlem Yedier-Bayram
Ahmet Cingöz
Tugba Bagci-Onder
ResearchOpen Access30 Jun 2025
Experimental & Molecular Medicine

Volume: 57, P: 1294-1307
Enhancing single-cell transcriptomics using interposed anchor oligonucleotide sequences

Droplet-based sequencing is key to single-cell transcriptomics but faces challenges from bead synthesis errors. A new bead design with anchor sequences improves UMI identification, read recovery, and feature detection for both short- and long-read methods.

Jianfeng Sun
Martin Philpott
Adam P. Cribbs
ResearchOpen Access16 Jan 2025
Communications Biology

Volume: 8, P: 1-10
Novel biomarkers of a peripheral blood interferon signature associated with drug-naïve early arthritis patients distinguish persistent from self-limiting disease course

Attila A. Seyhan
Bernard Gregory
Peter C. Taylor
ResearchOpen Access01 Jun 2020
Scientific Reports

Volume: 10, P: 1-15
Invasive Salmonella exploits divergent immune evasion strategies in infected and bystander dendritic cell subsets

Salmonella employ a range of strategies to counter host defences during infection. Here, Aulicino et al. use single-cell RNA-sequencing to examine the effects of invasive and non-invasive strains of Salmonella, revealing discrete and divergent immune evasion strategies in infected and bystander dendritic cells.

Anna Aulicino
Kevin C. Rue-Albrecht
Alison Simmons
ResearchOpen Access19 Nov 2018
Nature Communications

Volume: 9, P: 1-17
Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study

APOE is the major genetic risk factor for Alzheimer’s disease. In a large number of neuropathologically confirmed cases and controls, the impact of different APOE genotypes on Alzheimer’s dementia risk was greater than previously thought and APOE2 homozygotes had an exceptionally low risk.

Eric M. Reiman
Joseph F. Arboleda-Velasquez
Yi Zhao
ResearchOpen Access03 Feb 2020
Nature Communications

Volume: 11, P: 1-11
Mapping the musculoskeletal system one cell at a time

The Human Cell Atlas (HCA) project aims to map tissues and organs during development, maturation and pathology at single cell resolution. The musculoskeletal HCA network is a community for fostering collaboration and shared expertise to help develop the therapeutic approaches needed to address the high global burden of musculoskeletal disorders.

Mathew J. Baldwin
Adam P. Cribbs
Sarah J. B. Snelling
Comments & Opinion12 Mar 2021
Nature Reviews Rheumatology

Volume: 17, P: 247-248
A community effort to track commercial single-cell and spatial ’omic technologies and business trends

There is an ever-growing choice of single-cell and spatial ’omics platforms for industry and academia. The scTrends Consortium provides a brief historical overview of the established platforms and companies, revealing market trends and presenting possible angles for how technologies may differentiate themselves.

Joachim De Jonghe
James W. Opzoomer
Jake P. Taylor-King
Comments & Opinion17 Jul 2024
Nature Biotechnology

Volume: 42, P: 1017-1023
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

Sven van der Lee, Julie Williams, Gerard Schellenberg and colleagues identify rare coding variants in PLCG2, ABI3 and TREM2 associated with Alzheimer's disease. These genes are highly expressed in microglia and provide additional evidence that the microglia-mediated immune response contributes to the development of Alzheimer's disease.

Rebecca Sims
Sven J van der Lee
Gerard D Schellenberg
Research17 Jul 2017
Nature Genetics

Volume: 49, P: 1373-1384
Evidence for light-by-light scattering in heavy-ion collisions with the ATLAS detector at the LHC

Quantum electrodynamics predicts a rare process in which light is scattered by light. The ATLAS Collaboration reports signs of this elusive effect in the collisions of ultra-relativistic lead ions.

M. Aaboud
G. Aad
L. Zwalinski
ResearchOpen Access14 Aug 2017
Nature Physics

Volume: 13, P: 852-858
Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Brian W. Kunkle
Benjamin Grenier-Boley
Margaret A. Pericak-Vance
Amendments and Corrections15 Aug 2019
Nature Genetics

Volume: 51, P: 1423-1424
Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis

David Whitcomb, Bernie Devlin and colleagues report the results of a genome-wide association study of pancreatitis. They identify common variants at two loci associated with risk of this disease, including one on the X chromosome that shows strong evidence of interaction with alcohol consumption.

David C Whitcomb
Jessica LaRusch
Bernie Devlin
Research11 Nov 2012
Nature Genetics

Volume: 44, P: 1349-1354
A roadmap for delivering a human musculoskeletal cell atlas

A single-cell atlas of the human musculoskeletal system could help to improve the understanding of musculoskeletal function in growth, homeostasis, ageing and disease. This Roadmap delineates the steps required and challenges involved in creating such an atlas.

Mathew Baldwin
Christopher D. Buckley
Sarah Snelling
Reviews05 Oct 2023
Nature Reviews Rheumatology

Volume: 19, P: 738-752
PRMT5 inhibition shows in vitro efficacy against H3K27M-altered diffuse midline glioma, but does not extend survival in vivo

Elizabeth J. Brown
Leire Balaguer-Lluna
Gillian Farnie
ResearchOpen Access03 Jan 2024
Scientific Reports

Volume: 14, P: 1-17
Prolyl-tRNA synthetase as a novel therapeutic target in multiple myeloma

Keiji Kurata
Anna James-Bott
Udo Oppermann
ResearchOpen Access12 Jan 2023
Blood Cancer Journal

Volume: 13, P: 1-12
EPIKOL, a chromatin-focused CRISPR/Cas9-based screening platform, to identify cancer-specific epigenetic vulnerabilities

Ozlem Yedier-Bayram
Bengul Gokbayrak
Tugba Bagci-Onder
ResearchOpen Access16 Aug 2022
Cell Death & Disease

Volume: 13, P: 1-11
Loss of mutual protection between human osteoclasts and chondrocytes in damaged joints initiates osteoclast-mediated cartilage degradation by MMPs

Quitterie C. Larrouture
Adam P. Cribbs
Helen J. Knowles
ResearchOpen Access22 Nov 2021
Scientific Reports

Volume: 11, P: 1-12
Manifestations of Alzheimer’s disease genetic risk in the blood are evident in a multiomic analysis in healthy adults aged 18 to 90

Laura Heath
John C. Earls
Yi Zhao
ResearchOpen Access12 Apr 2022
Scientific Reports

Volume: 12, P: 1-17
Overcoming barriers to single-cell RNA sequencing adoption in low- and middle-income countries

Tracy Boakye Serebour
Adam P. Cribbs
Sarah J. B. Snelling
ReviewsOpen Access02 Apr 2024
European Journal of Human Genetics

Volume: 32, P: 1206-1213
A novel Alzheimer disease locus located near the gene encoding tau protein

G Jun
C A Ibrahim-Verbaas
L A Farrer
Research17 Mar 2015
Molecular Psychiatry

Volume: 21, P: 108-117
Correction: Prolyl-tRNA synthetase as a novel therapeutic target in multiple myeloma

Keiji Kurata
Anna James-Bott
Udo Oppermann
Amendments and CorrectionsOpen Access07 Feb 2023
Blood Cancer Journal

Volume: 13, P: 1

Search

A systems-based approach to uterine fibroids identifies differential splicing associated with abnormal uterine bleeding

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Correcting PCR amplification errors in unique molecular identifiers to generate accurate numbers of sequencing molecules

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Nanopore sequencing of single-cell transcriptomes with scCOLOR-seq

Spatially and optically tailored 3D printing for highly miniaturized and integrated microfluidics

An essential role for the Zn²⁺ transporter ZIP7 in B cell development

Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming

Chromatin-focused genetic and chemical screens identify BRPF1 as a targetable vulnerability in Taxol-resistant triple-negative breast cancer

Enhancing single-cell transcriptomics using interposed anchor oligonucleotide sequences

Novel biomarkers of a peripheral blood interferon signature associated with drug-naïve early arthritis patients distinguish persistent from self-limiting disease course

Invasive Salmonella exploits divergent immune evasion strategies in infected and bystander dendritic cell subsets

Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study

Mapping the musculoskeletal system one cell at a time

A community effort to track commercial single-cell and spatial ’omic technologies and business trends

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

Evidence for light-by-light scattering in heavy-ion collisions with the ATLAS detector at the LHC

Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis

A roadmap for delivering a human musculoskeletal cell atlas

PRMT5 inhibition shows in vitro efficacy against H3K27M-altered diffuse midline glioma, but does not extend survival in vivo

Prolyl-tRNA synthetase as a novel therapeutic target in multiple myeloma

EPIKOL, a chromatin-focused CRISPR/Cas9-based screening platform, to identify cancer-specific epigenetic vulnerabilities

Loss of mutual protection between human osteoclasts and chondrocytes in damaged joints initiates osteoclast-mediated cartilage degradation by MMPs

Manifestations of Alzheimer’s disease genetic risk in the blood are evident in a multiomic analysis in healthy adults aged 18 to 90

Overcoming barriers to single-cell RNA sequencing adoption in low- and middle-income countries

A novel Alzheimer disease locus located near the gene encoding tau protein

Correction: Prolyl-tRNA synthetase as a novel therapeutic target in multiple myeloma

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